RNASEL

Gene Symbol RNASEL
Entrez Gene 6041
Alt Symbol PRCA1, RNS4
Species Human
Gene Type protein-coding
Description ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Other Description 2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4
Swissprots Q6AI46 Q5W0L2 Q05823
Accessions AAA18032 EAW91128 Q05823 AK315231 AW968304 BC090934 AAH90934 BC114433 AAI14434 BC115697 AAI15698 BQ003187 BQ006347 BU940316 BX097443 CB268440 CR627369 CAH10468 DA127960 DQ352452 ABC74581 XM_005245411 XP_005245468 NM_021133 NP_066956
Function Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269|PubMed:11585831}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
Tissue Specificity Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Top Pathways Hepatitis C, Influenza A, Herpes simplex infection

RNase L (2E9.2G5) - sc-23955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RNase L (2E9.2G5): sc-23955. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tissue showing cytoplasmic localization.

RNase L (C-17) - sc-22870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RNase L (E-9) - sc-74405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RNase L (E-9): sc-74405. Western blot analysis of RNase L expression in T98G whole cell lysate.

RNase L (H-300) - sc-25798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RNase L (H-300): sc-25798. Western blot analysis of RNase L expression of PC-3 (A) and DU 145 (B) nuclear extracts and F9 (C) and T98G (D) whole cell lysates.

RNase L (T-16) - sc-22871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RNase L (T-16): sc-22871. Western blot analysis of RNase L expression in T98G whole cell lysate.

RNase L (H-4) - sc-74416 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RNase L (H-4): sc-74416. Western blot analysis of RNase L expression in T98G whole cell lysate.

Anti-RNase L [EPR15894] antibody - ab191392 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15894
All lanes : Anti-RNase L [EPR15894] antibody (ab191392) at 1/50000 dilutionLane 1 : HeLa cell lysateLane 2 : Y79 cell lysateLane 3 : THP1 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-RNase L antibody - ab37422 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (C-Terminus) - LS-C31399 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (clone 2E9, Biotin) - LS-C141103 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E9

Anti-RNASEL / RNase L Antibody - LS-C38902 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RNASEL / RNase L Antibody (clone 2E9, DY650) - LS-C141104 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E9

Anti-RNASEL / RNase L Antibody (clone 2E9, HRP) - LS-C141106 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E9

Anti-RNASEL / RNase L Antibody (clone 2E9, DY488) - LS-C141105 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E9

Anti-RNASEL / RNase L Antibody (clone 2E9, DY550) - LS-C141107 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E9

Anti-RNASEL / RNase L Antibody (aa140-167, AP) - LS-C268350 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (aa140-167, Biotin) - LS-C268352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (aa140-167, APC) - LS-C268351 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (aa140-167, Azide-free, HRP) - LS-C268354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (aa140-167, FITC) - LS-C268355 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (aa140-167, PE) - LS-C268353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (Biotin) - LS-C318013 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (FITC) - LS-C318014 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (HRP) - LS-C318015 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RNASEL / RNase L Antibody (aa139-167) - LS-C324713 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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