RNASEL

Gene Symbol	RNASEL
Entrez Gene	6041
Alt Symbol	PRCA1, RNS4
Species	Human
Gene Type	protein-coding
Description	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Other Description	2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4
Swissprots	Q6AI46 Q5W0L2 Q05823
Accessions	AAA18032 EAW91128 Q05823 AK315231 AW968304 BC090934 AAH90934 BC114433 AAI14434 BC115697 AAI15698 BQ003187 BQ006347 BU940316 BX097443 CB268440 CR627369 CAH10468 DA127960 DQ352452 ABC74581 XM_005245411 XP_005245468 NM_021133 NP_066956
Function	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269|PubMed:11585831}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
Tissue Specificity	Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Top Pathways	Hepatitis C, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNase L protein fragment - ab152657 from Abcam Category Protein Source Wheat germ Species Human

RNASEL / RNase L Antibody Blocking Peptide - LS-E5034 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNASEL / RNase L Antibody Blocking Peptide - LS-E10645 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNase L Protein - H00006041-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Human RNASEL protein - orb246481 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

RNASEL Blocking Peptide - 33R-6150 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Ribonuclease L Protein - abx068927 from Abbexa Category Protein Source E.coli Species Human

RNASEL - H00006041-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

RNASEL - H00006041-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

RNASEL - H00006041-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

Ribonuclease L (RNASEL), Human - 20-8703 from ARP American Research Products Category Protein Prices $529.00 Sizes 50 µg Source E.coli Species Human

RNASEL fusion protein - Ag17409 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RNASEL fusion protein - ag16481 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RNASEL, His-tagged - RNASEL-2329H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Ribonuclease L (RNASEL) - RPD164Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Ribonuclease L (RNASEL) - RPD164Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human 2-5A-dependent ribonuclease - CSB-EP313223(F2) CSB-BP313223(F2) CSB-MP313223(F2) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human 2-5A-dependent ribonuclease - CSB-YP313223(F2) from Cusabio Category Protein Source E.coli Species Human

Recombinant Human 2-5A-dependent ribonuclease(RNASEL) - CSB-YP313223HU CSB-EP313223HU CSB-BP313223HU CSB-MP313223HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

2-5A-dependent ribonuclease (RNASEL), Recombinant Protein - MBS1041064 from MyBioSource Category Protein Prices $1,555.00, $1,555.00, $1,780.00, $1,780.00, $2,670.00, $2,670.00, $3,115.00, $3,115.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RNASEL - TP314849 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human RNASEL protein, MYC/DDK-tagged - RNASEL-39H from Creative Biomart Category Protein Source HEK293 Species Human

RNase L Recombinant Protein Antigen - NBP1-87230PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNASEL Peptide, Human - M34GP13359H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNASEL Recombinant Protein (OPCA01977) - OPCA01977 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Search more