RNASEL
| Gene Symbol | RNASEL |
|---|---|
| Entrez Gene | 6041 |
| Alt Symbol | PRCA1, RNS4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) |
| Other Description | 2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4 |
| Swissprots | Q6AI46 Q5W0L2 Q05823 |
| Accessions | AAA18032 EAW91128 Q05823 AK315231 AW968304 BC090934 AAH90934 BC114433 AAI14434 BC115697 AAI15698 BQ003187 BQ006347 BU940316 BX097443 CB268440 CR627369 CAH10468 DA127960 DQ352452 ABC74581 XM_005245411 XP_005245468 NM_021133 NP_066956 |
| Function | Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269|PubMed:11585831}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}. |
| Tissue Specificity | Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes. |
| Top Pathways | Hepatitis C, Influenza A, Herpes simplex infection |
RNase L CRISPR/Cas9 KO Plasmid (h) - sc-403412 from Santa Cruz Biotechnology
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RNase L HDR Plasmid (h) - sc-403412-HDR from Santa Cruz Biotechnology
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RNase L Double Nickase Plasmid (h) - sc-403412-NIC from Santa Cruz Biotechnology
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RNase L Double Nickase Plasmid (h2) - sc-403412-NIC-2 from Santa Cruz Biotechnology
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RNase L CRISPR Activation Plasmid (h) - sc-403412-ACT from Santa Cruz Biotechnology
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RNase L CRISPR Activation Plasmid (h2) - sc-403412-ACT-2 from Santa Cruz Biotechnology
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RNase L Lentiviral Activation Particles (h) - sc-403412-LAC from Santa Cruz Biotechnology
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RNase L Lentiviral Activation Particles (h2) - sc-403412-LAC-2 from Santa Cruz Biotechnology
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RNase L siRNA (h) - sc-45965 from Santa Cruz Biotechnology
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RNase L shRNA Plasmid (h) - sc-45965-SH from Santa Cruz Biotechnology
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RNase L shRNA (h) Lentiviral Particles - sc-45965-V from Santa Cruz Biotechnology
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RNase L RNAi - H00006041-R03 from Novus Biologicals
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MISSION® esiRNA - EHU036111 from Sigma-Aldrich
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MISSION® siRNA - SIHK1979 from Sigma-Aldrich
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MISSION® siRNA - SIHK1977 from Sigma-Aldrich
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MISSION® siRNA - SIHK1978 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18357 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18357 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10522 from Sigma-Aldrich
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RNASEL siRNA (Human) - CRH4091 from Cohesion Biosciences
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RNASEL - MBS8223101 from MyBioSource
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shRNA set against Human RNASEL (NM_021133.3) - SHH396417 from Creative biogene
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RNASEL shRNA Plasmid (Human) - CHH4091 from Cohesion Biosciences
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RNASEL miRNA 3'UTR clone - MiUTR3H-02045 from Creative biogene
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