| Gene Symbol |
RNASEL
|
| Entrez Gene |
6041
|
| Alt Symbol |
PRCA1, RNS4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
|
| Other Description |
2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4
|
| Swissprots |
Q6AI46 Q5W0L2 Q05823
|
| Accessions |
AAA18032 EAW91128 Q05823 AK315231 AW968304 BC090934 AAH90934 BC114433 AAI14434 BC115697 AAI15698 BQ003187 BQ006347 BU940316 BX097443 CB268440 CR627369 CAH10468 DA127960 DQ352452 ABC74581 XM_005245411 XP_005245468 NM_021133 NP_066956
|
| Function |
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269|PubMed:11585831}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
|
| Tissue Specificity |
Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
|
| Top Pathways |
Hepatitis C, Influenza A, Herpes simplex infection
|