RNASEL

Gene Symbol RNASEL
Entrez Gene 6041
Alt Symbol PRCA1, RNS4
Species Human
Gene Type protein-coding
Description ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Other Description 2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4
Swissprots Q6AI46 Q5W0L2 Q05823
Accessions AAA18032 EAW91128 Q05823 AK315231 AW968304 BC090934 AAH90934 BC114433 AAI14434 BC115697 AAI15698 BQ003187 BQ006347 BU940316 BX097443 CB268440 CR627369 CAH10468 DA127960 DQ352452 ABC74581 XM_005245411 XP_005245468 NM_021133 NP_066956
Function Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269|PubMed:11585831}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
Tissue Specificity Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Top Pathways Hepatitis C, Influenza A, Herpes simplex infection

Human RNASEL / RNase L ELISA Kit (Sandwich ELISA) - LS-F7656 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 6.5 pg/ml
Range 15.63-1000 pg/ml

Ribonuclease L (RNASEL), ELISA Kit - MBS2019751 from MyBioSource

Category ELISA Kit
Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 6.8pg/mL.
Range 15.63-1000pg/mL

ELISA Kit for Ribonuclease L (RNASEL) - SED164Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 6.8pg/mL.
Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

Ribonuclease L (RNASEL), Human, ELISA Kit - DL-RNASEL-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 15.6-1,000 pg/mL

Human RNASEL ELISA Kit - abx574929 from Abbexa

Category ELISA Kit
Sensitivity 7.3 pg/ml
Range 15.625 pg/ml - 1000 pg/ml

Human RNASEL ELISA Kit - E033623 from Biobool

Category ELISA Kit
Sensitivity Typically less than 6.8pg/mL.

RNASEL ELISA Kit (Human) (OKCD00189) - OKCD00189 from Aviva Systems Biology

Category ELISA Kit
Prices $545.00
Sizes 96 wells
Sensitivity < 6.5 pg/mL
Range 15.62-1,000 pg/mL

Ribonuclease L (RNASEL), ELISA Kit - MBS451954 from MyBioSource

Category ELISA Kit
Prices $415.00, $550.00, $2,425.00, $4,710.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <7.3pg/mL
Range 15.625-1000pg/mL

Ribonuclease L (RNASEL), ELISA Kit - MBS9379183 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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