RNASEL

Gene Symbol	RNASEL
Entrez Gene	6041
Alt Symbol	PRCA1, RNS4
Species	Human
Gene Type	protein-coding
Description	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Other Description	2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4
Swissprots	Q6AI46 Q5W0L2 Q05823
Accessions	AAA18032 EAW91128 Q05823 AK315231 AW968304 BC090934 AAH90934 BC114433 AAI14434 BC115697 AAI15698 BQ003187 BQ006347 BU940316 BX097443 CB268440 CR627369 CAH10468 DA127960 DQ352452 ABC74581 XM_005245411 XP_005245468 NM_021133 NP_066956
Function	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269|PubMed:11585831}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
Tissue Specificity	Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Top Pathways	Hepatitis C, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RNASEL - MBS1272159 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC115697

Human RNASEL/RNS4 Gene ORF cDNA clone in cloning vector - HG10858-M from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10858-CM from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, N-His tag - HG10858-NH from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10858-NY from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10858-ANG from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, C-His tag - HG10858-CH from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10858-ACG from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10858-ACR from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10858-ANR from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid - HG10858-UT from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10858-NF from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10858-NM from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10858-CY from Sino Biological Species Human

Human RNASEL/RNS4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10858-CF from Sino Biological Species Human

Human RNASEL ORF Clone (BC115697) - CDCS415287 from Creative biogene Species Human Accession Q05823

Human RNASEL gene - orb91502 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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