| Gene Symbol |
FURIN
|
| Entrez Gene |
5045
|
| Alt Symbol |
FUR, PACE, PCSK3, SPC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
furin (paired basic amino acid cleaving enzyme)
|
| Other Description |
FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin type 3
|
| Swissprots |
Q14336 Q9UCZ5 Q6LBS3 P09958
|
| Accessions |
CAA00605 CAA27860 CAA33745 EAX02111 EAX02112 P09958 AI051906 AL110107 AL555508 BC008295 BC012181 AAH12181 BM043834 BP282138 BP283962 S65442 AAB28140 X17094 CAA34948 NM_001289823 NP_001276752 NM_001289824 NP_001276753 NM_002569 NP_002560
|
| Function |
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:7690548}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
|
| Tissue Specificity |
Seems to be expressed ubiquitously.
|
| Top Pathways |
Influenza A
|