FURIN

Gene Symbol	FURIN
Entrez Gene	5045
Alt Symbol	FUR, PACE, PCSK3, SPC1
Species	Human
Gene Type	protein-coding
Description	furin (paired basic amino acid cleaving enzyme)
Other Description	FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin type 3
Swissprots	Q14336 Q9UCZ5 Q6LBS3 P09958
Accessions	CAA00605 CAA27860 CAA33745 EAX02111 EAX02112 P09958 AI051906 AL110107 AL555508 BC008295 BC012181 AAH12181 BM043834 BP282138 BP283962 S65442 AAB28140 X17094 CAA34948 NM_001289823 NP_001276752 NM_001289824 NP_001276753 NM_002569 NP_002560
Function	Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:7690548}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Tissue Specificity	Seems to be expressed ubiquitously.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active Furin full length protein - ab6032 from Abcam Category Protein Prices $239.00 Sizes 25 µl

Active human Furin protein fragment - ab167741 from Abcam Category Protein Prices $410.00 Sizes 20 µg Source HEK 293 cells Species Human

Furin peptide - ab41397 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Furin peptide - ab41398 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Furin peptide - ab4989 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Furin full length protein - ab159045 from Abcam Category Protein Source Wheat germ Species Human

Human Furin peptide - ab66678 from Abcam Category Peptide

Human Furin protein fragment - ab126908 from Abcam Category Protein Source High-5 insect cells Species Human

Human Furin protein fragment - ab203526 from Abcam Category Protein Source E. coli Species Human

FURIN Antibody Blocking Peptide - LS-E16580 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FURIN Antibody Blocking Peptide - LS-E27893 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FURIN Antibody Blocking Peptide - LS-E27894 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Furin Recombinant Protein - H00005045-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Furin recombinant protein - GTX53830 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source Hi-5 Insect cells

Recombinant Human Furin, CF - 1503-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp108-Glu715, with a C-terminal 10-His tag

E. coli FUR protein - orb81128 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Escherichia coli

FUR protein - 30R-1166 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

FURIN Blocking Peptide - 33R-7864 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Furin Blocking Peptide - 33R-10966 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Furin protein (His tag) - 80R-4162 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Human Furin Protein - abx066703 from Abbexa Category Protein Source E.coli Species Human

Human Furin Protein - abx066701 from Abbexa Category Protein Source E.coli Species Human

Human Furin Protein - abx066707 from Abbexa Category Protein Source E.coli Species Human

Furin Peptide - AC21-2816-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Furin - AR31069PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source High-5 Insect cells Species Human

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