FURIN

Gene Symbol FURIN
Entrez Gene 5045
Alt Symbol FUR, PACE, PCSK3, SPC1
Species Human
Gene Type protein-coding
Description furin (paired basic amino acid cleaving enzyme)
Other Description FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin type 3
Swissprots Q14336 Q9UCZ5 Q6LBS3 P09958
Accessions CAA00605 CAA27860 CAA33745 EAX02111 EAX02112 P09958 AI051906 AL110107 AL555508 BC008295 BC012181 AAH12181 BM043834 BP282138 BP283962 S65442 AAB28140 X17094 CAA34948 NM_001289823 NP_001276752 NM_001289824 NP_001276753 NM_002569 NP_002560
Function Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:7690548}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Tissue Specificity Seems to be expressed ubiquitously.
Top Pathways Influenza A

Furin (H-220) - sc-20801 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Furin (H-220): sc-20801. Immunoperoxidase staining of formalin fixed, paraffin-embedded human salivary gland tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Furin (G-6) - sc-133141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Furin (G-6): sc-133141. Western blot analysis of human recombinant Furin.

Furin (K-15) - sc-12485 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Furin (B-6) - sc-133142 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Furin (B-6): sc-133142. Western blot analysis of human recombinant Furin.

Furin (T-20) - sc-12484 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Furin antibody - ab3467 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunolocalization of endogenous furin in mouse 3T3 cells with ab3467.

Anti-Furin antibody - ab28548 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Furin antibody (ab28548) at 1/1000 dilutionLane 1 : Furin at 0.05 µgLane 2 : Furin at 0.01 µgLane 3 : Furin at 0.001 µg

Anti-Furin antibody [EPR14674] - ab183495 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14674
Immunocytochemical analysis of HepG2 cells fixed in 4% paraformaldehyde labeling ab183495 at 1/250 dilution and Goat anti rabbit IgG(Alexa Fluor® 555) at 1/200.  Counterstained with DAPI.

Anti-Furin antibody [MM0298-4G31] - ab89558 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0298-4G31
Overlay histogram showing HeLa cells stained with ab89558 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab89558, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Unlabelled sample (blue line). Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Furin antibody - Aminoterminal end - ab28547 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Furin antibody - Aminoterminal end (ab28547) at 1/1000 dilutionLane 1 : Furin at 0.05 µgLane 2 : Furin at 0.01 µgLane 3 : Furin at 0.001 µg

Anti-Prohormone convertase 1 + 2 + 3 antibody - ab54084 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (aa740-790) IHC-plus™ - LS-B7236 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FURIN antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7236 concentration 5 ug/ml.

Anti-FURIN Antibody - LS-C23718 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-FURIN Antibody (clone MON-150) - LS-C23721 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone MON-150

Anti-FURIN Antibody - LS-C23720 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (clone MON-148) - LS-C23722 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone MON-148

Anti-FURIN Antibody (clone MON-139) - LS-C23723 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone MON-139

Anti-FURIN Antibody (aa73-90) - LS-C149000 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (aa779) - LS-C190198 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (aa418-573, Biotin) - LS-C297102 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (aa553-565) - LS-C186498 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
FURIN antibody (2 ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

Anti-FURIN Antibody (aa107-156) - LS-C111020 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FURIN antibody LS-C111020 Western blot of THP-1 cell lysate.

Anti-FURIN Antibody (aa385-500, Biotin) - LS-C300133 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (aa105-221, FITC) - LS-C304447 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FURIN Antibody (aa385-500, FITC) - LS-C302051 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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