FURIN

Gene Symbol FURIN
Entrez Gene 5045
Alt Symbol FUR, PACE, PCSK3, SPC1
Species Human
Gene Type protein-coding
Description furin (paired basic amino acid cleaving enzyme)
Other Description FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin type 3
Swissprots Q14336 Q9UCZ5 Q6LBS3 P09958
Accessions CAA00605 CAA27860 CAA33745 EAX02111 EAX02112 P09958 AI051906 AL110107 AL555508 BC008295 BC012181 AAH12181 BM043834 BP282138 BP283962 S65442 AAB28140 X17094 CAA34948 NM_001289823 NP_001276752 NM_001289824 NP_001276753 NM_002569 NP_002560
Function Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:7690548}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Tissue Specificity Seems to be expressed ubiquitously.
Top Pathways Influenza A

Furin CRISPR/Cas9 KO Plasmid (h) - sc-400904 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin HDR Plasmid (h) - sc-400904-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin Double Nickase Plasmid (h) - sc-400904-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin Double Nickase Plasmid (h2) - sc-400904-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin CRISPR Activation Plasmid (h) - sc-400904-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin CRISPR Activation Plasmid (h2) - sc-400904-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin Lentiviral Activation Particles (h) - sc-400904-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin Lentiviral Activation Particles (h2) - sc-400904-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin siRNA (h) - sc-40595 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Furin shRNA Plasmid (h) - sc-40595-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Furin shRNA (h) Lentiviral Particles - sc-40595-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Furin RNAi - H00005045-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8994 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8994 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09865 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09865

FURIN siRNA (Human) - CRH3351 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FURIN - MBS8227234 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Furin CRISPR/Cas9 KO Plasmid (h2) - sc-400904-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Furin HDR Plasmid (h2) - sc-400904-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human FUR (NM_002569.2) - SHH297709 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FURIN(NM_002569.2) - SHH070183 from Creative biogene

Category siRNA
Species Reactivities Human

Human FURIN siRNA - orb263853 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FURIN shRNA Plasmid (Human) - CHH3351 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FURIN miRNA 3'UTR clone - MiUTR1H-03876 from Creative biogene

Species Reactivities Human
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