BLK

Gene Symbol BLK
Entrez Gene 640
Alt Symbol MODY11
Species Human
Gene Type protein-coding
Description BLK proto-oncogene, Src family tyrosine kinase
Other Description B lymphoid tyrosine kinase|BLK nonreceptor tyrosine kinase|b lymphocyte kinase|p55-Blk|tyrosine-protein kinase Blk
Swissprots P51451 Q16291 Q96IN1
Accessions EAW65617 EAW65618 P51451 AK313751 BAG36491 AL832875 BC004473 BC007371 AAH07371 BC018703 AAH18703 BC032413 AAH32413 BC038555 BQ057058 S76617 AAB33265 Z33998 CAA83965 XM_011543824 XP_011542126 XM_011543825 XP_011542127 XM_011543826 XP_011542128 XM_011543827 XP_011542129 XM_011543828 XP_011542130 XM_011543829 XP_011542131 NM_001715 NP_001706
Function Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In p
Subcellular Location Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}.

Blk Antibody - 3262 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of Namalwa (lane 1) and HuT 78 (lane 2) cells grown in media with 10% FBS, using Blk Antibody.

Blk (F-1) - sc-393996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blk (F-1): sc-393996. Western blot analysis of Blk expression in Ramos (A), NAMALWA (B) and Raji (C) whole cell lysates.

Blk (G-5) - sc-376597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blk (G-5): sc-376597. Western blot analysis of Blk expression in Ramos (A) and NAMALWA (B) whole cell lysates.

Blk (G-8) - sc-393960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blk (G-8): sc-393960. Western blot analysis of Blk expression in Ramos (A) and NAMALWA (B) whole cell lysates.

Blk (C-20) - sc-938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Blk (C-20): sc-938. Western blot analysis of Blk expression in NAMALWA (A) and Ramos (B) whole cell lysates.

Blk (9D10D1) - sc-65980 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blk (9D10D1): sc-65980. Western blot analysis of Blk expression in NAMALWA (A), Ramos (B), Raji (C), BJAB (D), HuT 78 (E) and Daudi (F) whole cell lysates.

Blk (K-23) - sc-329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Blk (K-23): sc-329. Western blot analysis of Blk expression in NAMALWA (A) and Ramos (B) whole cell lysates.

Blk (9D10B7H6) - sc-65939 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Blk (9D10B7H6): sc-65939. Western blot analysis of Blk expression in NAMALWA (A), Ramos (B) and Raji (C) whole cell lysates.

Anti-BLK (phospho Y388) antibody [EPR2111(2)] - ab151726 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR2111(2)
All lanes : Anti-BLK (phospho Y388) antibody [EPR2111(2)] (ab151726) at 1/1000 dilutionLane 1 : Ramos cell lysate, untreatedLane 2 : Ramos cell lysate, treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-BLK (phospho Y501) antibody - ab111889 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111889 at 1/50 dilution staining BLK in paraffin-embedded Human Breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-BLK (phospho Y501) antibody - ab192670 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling BLK (phospho Y501) with ab192670 at 1/50 dilution in the absence (left) or presence (right) of blocking peptide.

Anti-BLK antibody - ab37830 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-BLK antibody (ab37830) at 1/100 dilution + Mouse kidney tissue lysateSecondaryHRP-anti rabbitdeveloped using the ECL technique

Anti-BLK antibody - ab54866 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-BLK antibody - ab112542 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-BLK antibody (ab112542) at 0.1 µg/ml + Human Thymus lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-BLK antibody [1E6] - ab107240 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1E6
All lanes : Anti-BLK antibody [1E6] (ab107240) at 1/500 dilutionLane 1 : Non-transfected HEK293 cell lysateLane 2 : BLK-hIgGFc transfected HEK293 cell lysate

Anti-BLK antibody [9D10A8F8] - ab47700 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9D10A8F8
Anti-BLK antibody [9D10A8F8] (ab47700) at 1/500 dilution + Truncated BLK recombinant protein

Anti-BLK antibody - N-terminal - ab189320 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human spleen tissue labeling BLK with ab189320 at 3.75 µg/ml.

Anti-BLK Antibody (C-Terminus) - LS-C4177 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BLK Antibody - LS-C4184 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BLK Antibody (clone 9D10B7H6) - LS-C77067 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9D10B7H6

Anti-BLK Antibody (clone 9D10D1) - LS-C77043 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 9D10D1

Anti-BLK Antibody (clone 9D10D1) - LS-C47180 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9D10D1

Anti-BLK Antibody (N-Terminus) - LS-C188878 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-BLK Antibody (clone 9D10B7H6, 9D10A8F8) - LS-C47182 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-BLK Antibody - LS-C48221 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of BLK antibody LS-C48221.
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