| Gene Symbol |
BLK
|
| Entrez Gene |
640
|
| Alt Symbol |
MODY11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BLK proto-oncogene, Src family tyrosine kinase
|
| Other Description |
B lymphoid tyrosine kinase|BLK nonreceptor tyrosine kinase|b lymphocyte kinase|p55-Blk|tyrosine-protein kinase Blk
|
| Swissprots |
P51451 Q16291 Q96IN1
|
| Accessions |
EAW65617 EAW65618 P51451 AK313751 BAG36491 AL832875 BC004473 BC007371 AAH07371 BC018703 AAH18703 BC032413 AAH32413 BC038555 BQ057058 S76617 AAB33265 Z33998 CAA83965 XM_011543824 XP_011542126 XM_011543825 XP_011542127 XM_011543826 XP_011542128 XM_011543827 XP_011542129 XM_011543828 XP_011542130 XM_011543829 XP_011542131 NM_001715 NP_001706
|
| Function |
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In p
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}.
|
