BLK

Gene Symbol	BLK
Entrez Gene	640
Alt Symbol	MODY11
Species	Human
Gene Type	protein-coding
Description	BLK proto-oncogene, Src family tyrosine kinase
Other Description	B lymphoid tyrosine kinase|BLK nonreceptor tyrosine kinase|b lymphocyte kinase|p55-Blk|tyrosine-protein kinase Blk
Swissprots	P51451 Q16291 Q96IN1
Accessions	EAW65617 EAW65618 P51451 AK313751 BAG36491 AL832875 BC004473 BC007371 AAH07371 BC018703 AAH18703 BC032413 AAH32413 BC038555 BQ057058 S76617 AAB33265 Z33998 CAA83965 XM_011543824 XP_011542126 XM_011543825 XP_011542127 XM_011543826 XP_011542128 XM_011543827 XP_011542129 XM_011543828 XP_011542130 XM_011543829 XP_011542131 NM_001715 NP_001706
Function	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In p
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BLK ELISA Kit (Sandwich ELISA) - LS-F9113 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.071 ng/ml Range 0.156-10 ng/ml

Phosphotyrosine BLK / Tyrosine-protein Kinase Blk ELISA Kit - RAB0936 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human BLK ELISA Kit - abx150814 from Abbexa Category ELISA Kit Sensitivity 0.071 ng/ml Range 0.156 ng/ml - 10 ng/ml

B-Lymphoid Tyrosine Kinase (BLK), Human, ELISA Kit - SEE269Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.071ng/mL Range 0.156-10ng/mL

BLK (Human) IP-WB Antibody Pair - H00000640-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BLK (Human) Matched Antibody Pair - H00000640-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

B lymphoid tyrosine kinase, ELISA Kit - MBS9326320 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-Lymphoid Tyrosine Kinase (BLK), ELISA Kit - MBS2022081 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.071ng/mL. Range 0.156-10ng/mL

Protein tyrosine kinase, ELISA Kit - MBS748555 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS022290 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS040212 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS005142 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS010284 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS009521 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS040498 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS025400 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS094010 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine kinase, ELISA Kit - MBS725062 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS021071 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine kinase, ELISA Kit - MBS749655 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine kinase, ELISA Kit - MBS748123 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS039019 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS107388 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Tyrosine Kinase, ELISA Kit - MBS066178 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine kinase, ELISA Kit - MBS754051 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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