BLK
| Gene Symbol | BLK |
|---|---|
| Entrez Gene | 640 |
| Alt Symbol | MODY11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BLK proto-oncogene, Src family tyrosine kinase |
| Other Description | B lymphoid tyrosine kinase|BLK nonreceptor tyrosine kinase|b lymphocyte kinase|p55-Blk|tyrosine-protein kinase Blk |
| Swissprots | P51451 Q16291 Q96IN1 |
| Accessions | EAW65617 EAW65618 P51451 AK313751 BAG36491 AL832875 BC004473 BC007371 AAH07371 BC018703 AAH18703 BC032413 AAH32413 BC038555 BQ057058 S76617 AAB33265 Z33998 CAA83965 XM_011543824 XP_011542126 XM_011543825 XP_011542127 XM_011543826 XP_011542128 XM_011543827 XP_011542129 XM_011543828 XP_011542130 XM_011543829 XP_011542131 NM_001715 NP_001706 |
| Function | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In p |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}. |
Blk CRISPR/Cas9 KO Plasmid (h) - sc-402737 from Santa Cruz Biotechnology
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Blk HDR Plasmid (h) - sc-402737-HDR from Santa Cruz Biotechnology
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Blk Double Nickase Plasmid (h) - sc-402737-NIC from Santa Cruz Biotechnology
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Blk Double Nickase Plasmid (h2) - sc-402737-NIC-2 from Santa Cruz Biotechnology
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Blk CRISPR Activation Plasmid (h) - sc-402737-ACT from Santa Cruz Biotechnology
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Blk CRISPR Activation Plasmid (h2) - sc-402737-ACT-2 from Santa Cruz Biotechnology
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Blk Lentiviral Activation Particles (h) - sc-402737-LAC from Santa Cruz Biotechnology
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Blk Lentiviral Activation Particles (h2) - sc-402737-LAC-2 from Santa Cruz Biotechnology
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Blk siRNA (h) - sc-39227 from Santa Cruz Biotechnology
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Blk shRNA Plasmid (h) - sc-39227-SH from Santa Cruz Biotechnology
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Blk shRNA (h) Lentiviral Particles - sc-39227-V from Santa Cruz Biotechnology
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Blk RNAi - H00000640-R02 from Novus Biologicals
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MISSION® esiRNA - EHU142991 from Sigma-Aldrich
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MISSION® siRNA - SIHK0164 from Sigma-Aldrich
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MISSION® siRNA - SIHK0165 from Sigma-Aldrich
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MISSION® siRNA - SIHK0166 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3987 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3987 from Sigma-Aldrich
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BLK siRNA (Human) - CRH0436 from Cohesion Biosciences
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BLK - MBS8206388 from MyBioSource
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shRNA set against Human BLK (NM_001715.2) - SHH246854 from Creative biogene
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shRNA set against Human BLK(NM_001715.2) - SHG100977 from Creative biogene
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BLK shRNA Plasmid (Human) - CHH0436 from Cohesion Biosciences
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BLK miRNA 3'UTR clone - MiUTR3H-02337 from Creative biogene
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