BLK

Gene Symbol	BLK
Entrez Gene	640
Alt Symbol	MODY11
Species	Human
Gene Type	protein-coding
Description	BLK proto-oncogene, Src family tyrosine kinase
Other Description	B lymphoid tyrosine kinase|BLK nonreceptor tyrosine kinase|b lymphocyte kinase|p55-Blk|tyrosine-protein kinase Blk
Swissprots	P51451 Q16291 Q96IN1
Accessions	EAW65617 EAW65618 P51451 AK313751 BAG36491 AL832875 BC004473 BC007371 AAH07371 BC018703 AAH18703 BC032413 AAH32413 BC038555 BQ057058 S76617 AAB33265 Z33998 CAA83965 XM_011543824 XP_011542126 XM_011543825 XP_011542127 XM_011543826 XP_011542128 XM_011543827 XP_011542129 XM_011543828 XP_011542130 XM_011543829 XP_011542131 NM_001715 NP_001706
Function	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In p
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-BLK-cDNA-Clone - DC02143 from Abgent, a WuXi AppTec company Prices $681.75 Sizes 10 µg Species Human Accession BC007371

BLK - MBS1267188 from MyBioSource Species Human Accession BC007371

Human BLK Kinase Gene ORF cDNA clone in cloning vector - HG10782-M from Sino Biological Species Human

Human BLK Kinase Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10782-M-N from Sino Biological Species Human Accession NM_001715.2

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10782-M-F from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10782-NF from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10782-NM from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10782-CF from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-HA tag - HG10782-CY from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, N-His tag - HG10782-NH from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10782-ANG from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10782-CM from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, N-HA tag - HG10782-NY from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-His tag - HG10782-CH from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10782-ACR from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10782-ANR from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10782-ACG from Sino Biological Species Human

Human BLK Kinase Gene ORF cDNA clone expression plasmid - HG10782-UT from Sino Biological Species Human

BLK - CL01243H01 from Elabscience Species Human Accession NM_001715.2

Human BLK ORF clone(NM_001715.2) - CDCL182861 from Creative biogene Species Human

Human BLK ORF Clone (BC007371) - CDCS410393 from Creative biogene Species Human Accession P51451

Human BLK cDNA Clone(NM_001715.2) - CDFH001828 from Creative biogene Species Human

Human BLK cDNA Clone(NM_001715.2) - CDFH001829 from Creative biogene Species Human

Human BLK cDNA Clone(NM_001715.2) - CDFH001830 from Creative biogene Species Human

Human BLK cDNA Clone(NM_001715.2) - CDFH001831 from Creative biogene Species Human

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