BLK

Gene Symbol	BLK
Entrez Gene	640
Alt Symbol	MODY11
Species	Human
Gene Type	protein-coding
Description	BLK proto-oncogene, Src family tyrosine kinase
Other Description	B lymphoid tyrosine kinase|BLK nonreceptor tyrosine kinase|b lymphocyte kinase|p55-Blk|tyrosine-protein kinase Blk
Swissprots	P51451 Q16291 Q96IN1
Accessions	EAW65617 EAW65618 P51451 AK313751 BAG36491 AL832875 BC004473 BC007371 AAH07371 BC018703 AAH18703 BC032413 AAH32413 BC038555 BQ057058 S76617 AAB33265 Z33998 CAA83965 XM_011543824 XP_011542126 XM_011543825 XP_011542127 XM_011543826 XP_011542128 XM_011543827 XP_011542129 XM_011543828 XP_011542130 XM_011543829 XP_011542131 NM_001715 NP_001706
Function	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In p
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BLK full length protein - ab60876 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human BLK full length protein - ab113606 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source Baculovirus infected High-5 cells Species Human

Human BLK full length protein - ab157962 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BLK full length protein - ab172848 from Abcam Category Protein Prices $147.00 Sizes 10 µg Source E. coli Species Human

Human BLK protein fragment - ab157963 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BLK Antibody Blocking Peptide - LS-E27613 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BLK Antibody Blocking Peptide - LS-E16784 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BLK Antibody Blocking Peptide - LS-E9205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Blk Protein - H00000640-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Blk Partial Recombinant Protein - H00000640-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Blk Recombinant Protein - P4207 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Blk Recombinant Protein - P3841 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Blk Recombinant Protein - P4635 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Blk Protein - NBP1-99485 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Recombinant Human Blk Protein - NBP1-72465 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E.coli Species Human

Blk Peptide - P2742 from Novus Biologicals Category Peptide Species Human

BLK-Antibody-N-term-Blocking-Peptide - BP7697a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BLK (Active) recombinant protein - GTX65013 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active Blk, CF - 2679-KS-010 from R&D Systems Category Protein

Human BLK GST tag protein - orb84175 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Insect Species Human

Human BLK protein - orb167983 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human Blk R protein - orb163491 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

BLK Blocking Peptide - 33R-1621 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BLK protein - 30R-2838 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

BLK protein (His tag) - 80R-1979 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source Hi-5 cells

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