| Gene Symbol |
PMAIP1
|
| Entrez Gene |
5366
|
| Alt Symbol |
APR, NOXA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phorbol-12-myristate-13-acetate-induced protein 1
|
| Other Description |
PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
|
| Swissprots |
Q8N589 Q13794 B2R4T7
|
| Accessions |
Q13794 AK311943 BAG34884 BC013120 AAH13120 BC032663 AAH32663 BF667112 BM999509 D90070 BAA14111 JF432472 ADZ15689 NM_021127 NP_066950
|
| Function |
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
|
| Tissue Specificity |
Highly expressed in adult T-cell leukemia cell line.
|
| Top Pathways |
p53 signaling pathway, Viral carcinogenesis
|
![Western Blot: Noxa Overexpression Lysate (Adult Normal) [NBL1-14534] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Noxa.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7464_Noxa%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14534-img0002.jpg)