PMAIP1

Gene Symbol PMAIP1
Entrez Gene 5366
Alt Symbol APR, NOXA
Species Human
Gene Type protein-coding
Description phorbol-12-myristate-13-acetate-induced protein 1
Other Description PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
Swissprots Q8N589 Q13794 B2R4T7
Accessions Q13794 AK311943 BAG34884 BC013120 AAH13120 BC032663 AAH32663 BF667112 BM999509 D90070 BAA14111 JF432472 ADZ15689 NM_021127 NP_066950
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
Tissue Specificity Highly expressed in adult T-cell leukemia cell line.
Top Pathways p53 signaling pathway, Viral carcinogenesis

Noxa (D8L7U) Rabbit mAb - 14766 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8L7U
Western blot analysis of extracts from KARPAS-299, RL-7, and L-540 cells lines using Noxa (D8L7U) Rabbit mAb. Cell Line Source: Dr. Abraham Karpas at the University of Cambridge.

NOXA (FL-54) - sc-30209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NOXA (FL-54): sc-30209. Western blot analysis of NOXA expression in Jurkat (A), U-937 (B), RAW 264.7 (C) and HUT 78 (D) whole cell lysates.

NOXA (N-15) - sc-26917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NOXA (N-15): sc-26917. Western blot analysis of NOXA expression in non-transfected: sc-117752 (A) and human NOXA transfected: sc-117157 (B) 293T whole cell lysates.

NOXA (M-16) - sc-26919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NOXA (114C307) - sc-56169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NOXA (114C307): sc-56169. Western blot analysis of NOXA expression in U-698-M whole cell lysate.

Anti-Noxa antibody - ab36833 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Noxa antibody (ab36833) at 0.5 µg/ml + Human stomach cell lysate

Anti-Noxa antibody - ab85946 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Noxa antibody (ab85946) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Noxa antibody - ab117413 from Abcam

Host Rabbit
Clonality Polyclonal
ab117413, at 5 ug/ml, staining Noxa in formalin fixed, paraffin embedded Human Pancreas. Developed using biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Noxa antibody [114C307] - ab13654 from Abcam

Prices $392.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 114C307
Western blot detection of Noxa in RL-7 cell (a follicular lymphoma) lysate. A protein of approximate molecular weight of 11 kDa is detected using ab13654 at 2 µg/ml.

Anti-Noxa antibody [EPR9735(B)] - ab140129 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9735(B)
All lanes : Anti-Noxa antibody [EPR9735(B)] (ab140129) at 1/1000 dilutionLane 1 : LnCaP cell lysateLane 2 : HuT-78 cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PMAIP1 / NOXA Antibody (clone 114C307.1) - LS-C571 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 114C307.1
Western blot detection of Noxa in RL-7 cell (a follicular lymphoma) lysate. A protein of approximate molecular weight of 11 kD is detected using antibody at 2 ug/ml.

Anti-PMAIP1 / NOXA Antibody (aa75-90) - LS-C73721 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PMAIP1 / NOXA Antibody (aa1-16) - LS-C73720 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PMAIP1 / NOXA Antibody - LS-C74987 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PMAIP1 / NOXA Antibody (clone 114C307.1, Biotin) - LS-C148149 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 114C307.1

Anti-PMAIP1 / NOXA Antibody (N-Terminus) - LS-C189129 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PMAIP1 / NOXA Antibody - LS-C48607 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NOXA antibody LS-C48607.

Anti-PMAIP1 / NOXA Antibody (aa27-41) - LS-C108110 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PMAIP1 antibody (0.03 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PMAIP1 / NOXA Antibody (aa51-66) IHC-plus™ - LS-B121 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NOXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B121 concentration 10 ug/ml.

Anti-PMAIP1 / NOXA Antibody (N-Terminus) IHC-plus™ - LS-B184 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NOXA antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B184 concentration 5 ug/ml.

Anti-PMAIP1 / NOXA Antibody (N-Terminus) - LS-C9653 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PMAIP1 / NOXA Antibody (clone 114C307.1) - LS-C16939 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 114C307.1

Noxa Antibody (114C307.1) - NB600-1159 from Novus Biologicals

Prices $99.00, $349.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 114C307.1
Western Blot: Noxa Antibody (114C307.1) [NB600-1159] - Analysis using Azide Free version of NB600-1159. A) 293 cells transfected with human Noxa, B) RL-7 cell (a follicular lymphoma) and C) T98G lysate.

Noxa Antibody - NBP1-03106 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Noxa Antibody - NBP1-44061 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Noxa Antibody [NBP1-44061] - (0.03ug/ml) staining of Human Cer(35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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