PMAIP1

Gene Symbol PMAIP1
Entrez Gene 5366
Alt Symbol APR, NOXA
Species Human
Gene Type protein-coding
Description phorbol-12-myristate-13-acetate-induced protein 1
Other Description PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
Swissprots Q8N589 Q13794 B2R4T7
Accessions Q13794 AK311943 BAG34884 BC013120 AAH13120 BC032663 AAH32663 BF667112 BM999509 D90070 BAA14111 JF432472 ADZ15689 NM_021127 NP_066950
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
Tissue Specificity Highly expressed in adult T-cell leukemia cell line.
Top Pathways p53 signaling pathway, Viral carcinogenesis

NOXA CRISPR/Cas9 KO Plasmid (h) - sc-400498 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA HDR Plasmid (h) - sc-400498-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA Double Nickase Plasmid (h) - sc-400498-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA Double Nickase Plasmid (h2) - sc-400498-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA CRISPR Activation Plasmid (h) - sc-400498-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA CRISPR Activation Plasmid (h2) - sc-400498-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA Lentiviral Activation Particles (h) - sc-400498-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA Lentiviral Activation Particles (h2) - sc-400498-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA siRNA (h) - sc-37305 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOXA shRNA Plasmid (h) - sc-37305-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOXA shRNA (h) Lentiviral Particles - sc-37305-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Noxa RNAi - H00005366-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU078041 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17020 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17020 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10269 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10269

PMAIP1 siRNA (Human) - CRH3603 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PMAIP1(NM_021127.2) - SHR123406 from Creative biogene

Category siRNA
Species Reactivities Human

NOXA CRISPR/Cas9 KO Plasmid (h2) - sc-400498-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOXA HDR Plasmid (h2) - sc-400498-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PMAIP1 shRNA Plasmid (Human) - CHH3603 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PMAIP1 miRNA 3'UTR clone - MiUTR1H-08022 from Creative biogene

Species Reactivities Human
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