PMAIP1

Gene Symbol	PMAIP1
Entrez Gene	5366
Alt Symbol	APR, NOXA
Species	Human
Gene Type	protein-coding
Description	phorbol-12-myristate-13-acetate-induced protein 1
Other Description	PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
Swissprots	Q8N589 Q13794 B2R4T7
Accessions	Q13794 AK311943 BAG34884 BC013120 AAH13120 BC032663 AAH32663 BF667112 BM999509 D90070 BAA14111 JF432472 ADZ15689 NM_021127 NP_066950
Function	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
Tissue Specificity	Highly expressed in adult T-cell leukemia cell line.
Top Pathways	p53 signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PMAIP1 - MBS1277350 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC032663

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone) - HG16548-U from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged - HG16548-NM from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG16548-ACG from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 natural ORF mammalian expression plasmid, N-HA tag - HG16548-NY from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-GFPSpark-tagged - HG16548-ANG from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG16548-NH from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-tagged - HG16548-CF from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG16548-CH from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 natural ORF mammalian expression plasmid, N-Flag tag - HG16548-NF from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 natural ORF mammalian expression plasmid, C-OFPSpark / RFP tag - HG16548-ACR from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 natural ORF mammalian expression plasmid - HG16548-UT from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 natural ORF mammalian expression plasmid, N-OFPSpark tag - HG16548-ANR from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-tagged - HG16548-CM from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-tagged - HG16548-CY from Sino Biological Species Human Accession NM_021127.2

Human PMAIP1 ORF Clone (BC032663) - CDCS415280 from Creative biogene Species Human Accession Q13794

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