PMAIP1

Gene Symbol	PMAIP1
Entrez Gene	5366
Alt Symbol	APR, NOXA
Species	Human
Gene Type	protein-coding
Description	phorbol-12-myristate-13-acetate-induced protein 1
Other Description	PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
Swissprots	Q8N589 Q13794 B2R4T7
Accessions	Q13794 AK311943 BAG34884 BC013120 AAH13120 BC032663 AAH32663 BF667112 BM999509 D90070 BAA14111 JF432472 ADZ15689 NM_021127 NP_066950
Function	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
Tissue Specificity	Highly expressed in adult T-cell leukemia cell line.
Top Pathways	p53 signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Noxa full length protein - ab152618 from Abcam Category Protein Source Wheat germ Species Human

Human Noxa peptide - ab39823 from Abcam Category Peptide Species Human

PMAIP1 / NOXA Antibody Blocking Peptide - LS-E29963 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PMAIP1 / NOXA Antibody Blocking Peptide - LS-E26958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Noxa Protein - H00005366-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Noxa Blocking Peptide - NBP1-76763PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Noxa-BH3-Peptide-1 - SP2354b from Abgent, a WuXi AppTec company Category Peptide Prices $185.00 Sizes 1 mg

Noxa-BH3-Peptide-1 - SP2354a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 500 µg

Noxa-BH3-Peptide-1 - SP2353b from Abgent, a WuXi AppTec company Category Peptide Prices $185.00 Sizes 1 mg

Noxa-BH3-Peptide-1 - SP2353a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 500 µg

Noxa-BH3-Domain-Peptide - SP1020a from Abgent, a WuXi AppTec company Category Peptide Prices $165.00 Sizes 1 mg

Noxa blocking peptide - GTX88398-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Noxa Peptide - GTX85521-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Noxa Blocking Peptide - 33R-10863 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Noxa Peptide - AC21-1786-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NOXA - H00005366-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

NOXA Control Peptide - AP00312CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

NOXA Peptide - 42-144P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

NOXA fusion protein - Ag11733 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PMAIP1 fusion protein - ag11387 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PMAIP1, His-tagged - PMAIP1-1803H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) - CSB-YP018229HU CSB-EP018229HU CSB-BP018229HU CSB-MP018229HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Noxa Blocking Peptide - 3665BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

NOXA - TP302071 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), Recombinant Protein - MBS1403626 from MyBioSource Category Protein Prices $780.00, $780.00, $1,005.00, $1,005.00, $1,085.00, $1,085.00, $1,540.00, $1,540.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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