| Gene Symbol |
IL21
|
| Entrez Gene |
59067
|
| Alt Symbol |
CVID11, IL-21, Za11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 21
|
| Other Description |
interleukin-21|interleukin-21 isoform
|
| Swissprots |
A5J0L4 Q9HBE4
|
| Accessions |
AAU88182 CAI94500 CAJ47524 CAL81203 CAN87399 CAS03522 CAV33288 CBE74752 CBI70418 CBI85469 CBI85472 CBL93962 CCA63962 EAX05226 Q9HBE4 AF254069 AAG29348 BC066258 AAH66258 BC066259 AAH66259 BC066260 AAH66260 BC066261 AAH66261 BC066262 AAH66262 BC069124 AAH69124 CD559460 CD559613 DQ645417 ABG36529 HQ447458 ADQ31944 NM_001207006 NP_001193935 NM_021803 NP_068575
|
| Function |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:11081504}.
|
| Tissue Specificity |
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)
|
![Western Blot: IL21 Overexpression Lysate (Adult Normal) [NBP2-06520] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL21.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6788_IL21%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06520-img0001.jpg)