IL21

Gene Symbol	IL21
Entrez Gene	59067
Alt Symbol	CVID11, IL-21, Za11
Species	Human
Gene Type	protein-coding
Description	interleukin 21
Other Description	interleukin-21|interleukin-21 isoform
Swissprots	A5J0L4 Q9HBE4
Accessions	AAU88182 CAI94500 CAJ47524 CAL81203 CAN87399 CAS03522 CAV33288 CBE74752 CBI70418 CBI85469 CBI85472 CBL93962 CCA63962 EAX05226 Q9HBE4 AF254069 AAG29348 BC066258 AAH66258 BC066259 AAH66259 BC066260 AAH66260 BC066261 AAH66261 BC066262 AAH66262 BC069124 AAH69124 CD559460 CD559613 DQ645417 ABG36529 HQ447458 ADQ31944 NM_001207006 NP_001193935 NM_021803 NP_068575
Function	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11081504}.
Tissue Specificity	Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-IL21-cDNA-Clone - DC08537 from Abgent, a WuXi AppTec company Prices $218.70 Sizes 10 µg Species Human Accession BC066258

IL21 - MBS1276231 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC066262

IL21 - MBS1278379 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC066259

Human IL21 ORF Clone(NM_021803.3) - CDCL167128 from Creative Biomart Species Human Accession NM_021803.3

Human IL21/IL-21 Gene ORF cDNA clone in cloning vector - HG10584-M from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10584-CM from Sino Biological Species Human

Human IL21 Gene cDNA Clone (Codon Optimized, full-length ORF Clone), expression ready, N-HA-tagged - HG10584-NY from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-His tag - HG10584-CH from Sino Biological Species Human

Human IL21 Gene cDNA Clone (Codon Optimized, full-length ORF Clone) expression ready, untagged - HG10584-M-N from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10584-ACR from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid - HG10584-UT from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10584-ACG from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, N-His tag - HG10584-NH from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10584-NF from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10584-NM from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10584-CY from Sino Biological Species Human

Human IL21 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10584-M-F from Sino Biological Species Human

Human IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10584-CF from Sino Biological Species Human

Rhesus IL21/IL-21 Gene ORF cDNA clone expression plasmid, N-His tag - CG90298-NH from Sino Biological Species Monkey

Rhesus IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-His tag - CG90298-CH from Sino Biological Species Monkey

Rhesus IL21/IL-21 Gene ORF cDNA clone expression plasmid, N-HA tag - CG90298-NY from Sino Biological Species Monkey

Rhesus IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-HA tag - CG90298-CY from Sino Biological Species Monkey

Rhesus IL21/IL-21 Gene ORF cDNA clone expression plasmid, C-Myc tag - CG90298-CM from Sino Biological Species Monkey

Rhesus IL21/IL-21 Gene ORF cDNA clone expression plasmid - CG90298-UT from Sino Biological Species Monkey

Human IL21 ORF Clone (BC066262) - CDCS409689 from Creative biogene Species Human Accession Q9HBE4

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