IL21

Gene Symbol IL21
Entrez Gene 59067
Alt Symbol CVID11, IL-21, Za11
Species Human
Gene Type protein-coding
Description interleukin 21
Other Description interleukin-21|interleukin-21 isoform
Swissprots A5J0L4 Q9HBE4
Accessions AAU88182 CAI94500 CAJ47524 CAL81203 CAN87399 CAS03522 CAV33288 CBE74752 CBI70418 CBI85469 CBI85472 CBL93962 CCA63962 EAX05226 Q9HBE4 AF254069 AAG29348 BC066258 AAH66258 BC066259 AAH66259 BC066260 AAH66260 BC066261 AAH66261 BC066262 AAH66262 BC069124 AAH69124 CD559460 CD559613 DQ645417 ABG36529 HQ447458 ADQ31944 NM_001207006 NP_001193935 NM_021803 NP_068575
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.
Subcellular Location Secreted {ECO:0000269|PubMed:11081504}.
Tissue Specificity Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

IL-21 (C-17) - sc-17649 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-21 (N-20) - sc-17647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL21 antibody - ab53655 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
IHC image of IL21 staining in human Hodgkins lymphoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab53655, 5µg/ml, for 15 mins at room temperature. A donkey anti-goat biotinylated secondary antibody was used to detect the primary, and visualized using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-IL21 antibody - ab154767 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL21 antibody (ab154767) at 1/1000 dilution + HL60 whole cell lysate at 30 µg

Anti-IL21 antibody - ab118510 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Spleen (formalin-fixed, paraffin-embedded) stained with ab118510 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IL21 antibody - ab116562 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IL21 antibody (ab116562) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-IL21 antibody - ab167188 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IL21 antibody (ab167188) at 1/500 dilutionLane 1 : IL21 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-IL21 antibody [EPR4907] - ab178694 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4907
Anti-IL21 antibody [EPR4907] (ab178694) at 1/10000 dilution + Human IL21 recombinant protein at 0.005 µg

Anti-IL21 antibody [SB134f] - ab172199 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SB134f

Anti-IL21 Antibody (aa118-146) - LS-C8212 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (N-Terminus) - LS-C8216 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-IL21 Antibody (aa33-61) - LS-C83969 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IL21 Antibody (aa118-146) - LS-C83968 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (aa118-146) - LS-C83970 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (Biotin) - LS-C104548 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody - LS-C147101 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody - LS-C153090 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody - LS-C187693 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (aa33-61) - LS-C83971 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
IHC of IL-21 antibody LS-C83971. Mouse spleen.

Anti-IL21 Antibody (aa40-68) - LS-C187848 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-IL21 Antibody (Biotin) - LS-C190389 from LifeSpan Bioscience

Prices $590.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (aa125-153) - LS-C187847 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (aa24-152) - LS-C154024 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-bovine IL-21 Antibody - Western Blot. Western blot of anti-bovine IL-21 antibody shows detection of recombinant bovine IL-21 at 15.1kD (arrow) raised in yeast. Protein was purified and resolved by SDS-PAGE, transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Anti-bovine IL-21. After washing, membrane was probed with Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody (.

Anti-IL21 Antibody (aa110-139, AP) - LS-C236562 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL21 Antibody (aa110-139, APC) - LS-C236563 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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