IL21

Gene Symbol	IL21
Entrez Gene	59067
Alt Symbol	CVID11, IL-21, Za11
Species	Human
Gene Type	protein-coding
Description	interleukin 21
Other Description	interleukin-21|interleukin-21 isoform
Swissprots	A5J0L4 Q9HBE4
Accessions	AAU88182 CAI94500 CAJ47524 CAL81203 CAN87399 CAS03522 CAV33288 CBE74752 CBI70418 CBI85469 CBI85472 CBL93962 CCA63962 EAX05226 Q9HBE4 AF254069 AAG29348 BC066258 AAH66258 BC066259 AAH66259 BC066260 AAH66260 BC066261 AAH66261 BC066262 AAH66262 BC069124 AAH69124 CD559460 CD559613 DQ645417 ABG36529 HQ447458 ADQ31944 NM_001207006 NP_001193935 NM_021803 NP_068575
Function	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11081504}.
Tissue Specificity	Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL21 full length protein - ab179621 from Abcam Category Protein Prices $202.00 Sizes 10 µg Source E. coli Species Human

Active human IL21 full length protein - ab191780 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human IL21 full length protein - ab73250 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source E. coli Species Human

Active mouse IL21 full length protein - ab200258 from Abcam Category Protein Prices $107.00 Sizes 2 µg Source E. coli Species Mouse

Active rat IL21 full length protein - ab200267 from Abcam Category Protein Prices $107.00 Sizes 2 µg Source E. coli Species Rat

Active rat IL21 full length protein - ab125780 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Rat

Chicken IL21 full length protein - ab136370 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Yeast Species Chicken

Cow IL21 full length protein - ab87467 from Abcam Category Protein Prices $252.00 Sizes 25 µg Source Yeast Species Bovine

Dog IL21 full length protein - ab101290 from Abcam Category Protein Prices $252.00 Sizes 25 µg Source Yeast Species Dog

Human IL21 full length protein - ab191979 from Abcam Category Protein Source HEK 293 cells Species Human

Human IL21 full length protein - ab194160 from Abcam Category Protein Source Mammalian Species Human

Human IL21 full length protein - ab60287 from Abcam Category Protein Source E. coli Species Human

IL21 peptide - ab6680 from Abcam Category Peptide

Mouse IL21 full length protein - ab119463 from Abcam Category Protein Source E. coli Species Mouse

Mouse IL21 full length protein - ab93054 from Abcam Category Protein Source E. coli Species Mouse

IL21 Antibody Blocking Peptide - LS-E2748 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL21 Antibody Blocking Peptide - LS-E22226 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL21 Antibody Blocking Peptide - LS-E29968 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human IL-21 Protein - NBP2-35057 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

IL-21 Partial Recombinant Protein - H00059067-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

IL-21 Recombinant Protein - H00059067-P01 from Novus Biologicals Category Protein Species Human

IL-21 Blocking Peptide - NBP1-76740PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IL-21 Recombinant Protein - P3634 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL-21 Recombinant Protein - P4003 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

IL-21 Recombinant Protein - P4412 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

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