IL21

Gene Symbol IL21
Entrez Gene 59067
Alt Symbol CVID11, IL-21, Za11
Species Human
Gene Type protein-coding
Description interleukin 21
Other Description interleukin-21|interleukin-21 isoform
Swissprots A5J0L4 Q9HBE4
Accessions AAU88182 CAI94500 CAJ47524 CAL81203 CAN87399 CAS03522 CAV33288 CBE74752 CBI70418 CBI85469 CBI85472 CBL93962 CCA63962 EAX05226 Q9HBE4 AF254069 AAG29348 BC066258 AAH66258 BC066259 AAH66259 BC066260 AAH66260 BC066261 AAH66261 BC066262 AAH66262 BC069124 AAH69124 CD559460 CD559613 DQ645417 ABG36529 HQ447458 ADQ31944 NM_001207006 NP_001193935 NM_021803 NP_068575
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.
Subcellular Location Secreted {ECO:0000269|PubMed:11081504}.
Tissue Specificity Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

IL-21 CRISPR/Cas9 KO Plasmid (h) - sc-416409 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 HDR Plasmid (h) - sc-416409-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 Double Nickase Plasmid (h) - sc-416409-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 Double Nickase Plasmid (h2) - sc-416409-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 CRISPR Activation Plasmid (h) - sc-416409-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 CRISPR Activation Plasmid (h2) - sc-416409-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 Lentiviral Activation Particles (h) - sc-416409-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 Lentiviral Activation Particles (h2) - sc-416409-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-21 siRNA (h) - sc-39662 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-21 shRNA Plasmid (h) - sc-39662-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-21 shRNA (h) Lentiviral Particles - sc-39662-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-21 RNAi - H00059067-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU035511 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10607 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10607 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IL21 siRNA (Human) - CRJ1756 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL21 - MBS8240273 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IL21 (NM_021803.3) - SHH318689 from Creative biogene

Category siRNA
Species Reactivities Human

IL21 shRNA Plasmid (Human) - CHJ1756 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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