DKK1

Gene Symbol	DKK1
Entrez Gene	22943
Alt Symbol	DKK-1, SK
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 1
Other Description	dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1
Swissprots	O94907 B2RC19
Accessions	AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Subcellular Location	Secreted.
Tissue Specificity	Placenta.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DKK1 (Dickkopf-1) Human ELISA Kit - ab100501 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 100 pg/ml Range 122.9 pg/ml - 30000 pg/ml

Mouse DKK1 ELISA Kit (Sandwich ELISA) - LS-F2762 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15 pg/ml Range 122.9-12000 pg/ml

Human DKK1 ELISA Kit (Sandwich ELISA) - LS-F2731 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 122.9-12000 pg/ml

Human DKK1 ELISA Kit (Sandwich ELISA) - LS-F4835 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 122.9-12000 pg/ml

Human DKK1 ELISA Kit (Sandwich ELISA) - LS-F64 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 122.9 pg/ml Range 122.9-12000 pg/ml

Mouse DKK1 ELISA Kit (Sandwich ELISA) - LS-F234 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 24.58 pg/ml Range 122.9-12000 pg/ml

Human DKK1 ELISA Kit (Sandwich ELISA) - LS-F699 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 122.9-12000 pg/ml

Rat DKK1 ELISA Kit (Sandwich ELISA) - LS-F7704 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.27 ng/ml Range 122.9-12000 pg/ml

Mouse DKK1 ELISA Kit (Sandwich ELISA) - LS-F8743 from LifeSpan Bioscience Category ELISA Kit Prices $480.00 Sizes 1 plate Sensitivity 0.125 ng/ml Range 122.9-12000 pg/ml

Mouse DKK1 ELISA Kit (Sandwich ELISA) - LS-F10347 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 13.127 pg/ml Range 122.9-12000 pg/ml

Human Dkk-1 ELISA Kit - RAB0143 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human Dkk-1 Biotinylated Fluorokine Flow Cytometry Kit - NFDKK1 from R&D Systems Prices $405.00 Sizes 1 kit

Human Dkk-1 Quantikine ELISA Kit - DKK100 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 15.6 pg/mL Range 31.3 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Platelet-poor EDTA Plasma, Heparin Plasma, Platelet-poor Heparin Plasma), 9.4 - 600 pg/mL (Cell Culture Supernates, Serum-free Cell Culture Supern, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma),

Human Dkk-1 DuoSet ELISA - DY1906 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Mouse Dkk-1 Quantikine ELISA Kit - MKK100 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 29.6 pg/mL Range 62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Mouse Dkk-1 DuoSet ELISA - DY1765 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 46.90 - 3,000 pg/mL

Quantikine Immunoassay Control Set 736 for Human Dkk-1 - QC76 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221) - OKAG00221 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 63 pg/mL Range 63-4,000 pg/mL

Human DKK-1 ELISA Kit - orb96798 from Biorbyt Category ELISA Kit Prices $570.00 Sizes 96 well Sensitivity Less than 10 pg/ml

Human DKK1 ELISA Kit - abx054998 from Abbexa Category ELISA Kit Sensitivity 6 pg/ml Range 18 pg/ml -1000 pg/ml

Human DKK1 ELISA Kit - abx151322 from Abbexa Category ELISA Kit Sensitivity 33 pg/ml Range 78.125 pg/ml - 5000 pg/ml

Human DKK1 ELISA Kit - abx056136 from Abbexa Category ELISA Kit

Anti streptokinase (SK) antibody, Human, ELISA Kit - CSB-EQ027203HU from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Anti streptokinase (SK) antibody, Human, ELISA Kit - E01A2038 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Dickkopf 1, DKK1, Human, ELISA Kit - CSB-E10104h from ARP American Research Products Category ELISA Kit Prices $450.00, $595.00, $596.00, $599.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6pg/ml Range 62.5 pg/ml-4000pg/ml

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