DKK1

Gene Symbol	DKK1
Entrez Gene	22943
Alt Symbol	DKK-1, SK
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 1
Other Description	dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1
Swissprots	O94907 B2RC19
Accessions	AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Subcellular Location	Secreted.
Tissue Specificity	Placenta.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dkk-1 CRISPR/Cas9 KO Plasmid (h) - sc-400540 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 HDR Plasmid (h) - sc-400540-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 Double Nickase Plasmid (h) - sc-400540-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 Double Nickase Plasmid (h2) - sc-400540-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 CRISPR Activation Plasmid (h) - sc-400540-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 CRISPR Activation Plasmid (h2) - sc-400540-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 Lentiviral Activation Particles (h) - sc-400540-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 Lentiviral Activation Particles (h2) - sc-400540-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 siRNA (h) - sc-37082 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Dkk-1 shRNA Plasmid (h) - sc-37082-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Dkk-1 shRNA (h) Lentiviral Particles - sc-37082-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Dkk-1 RNAi - H00022943-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU035311 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1144 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1145 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1146 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1144 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1145 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

DKK1 siRNA (Human) - CRH7890 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DKK1 - MBS8220395 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Dkk-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400540-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Dkk-1 HDR Plasmid (h2) - sc-400540-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human DKK1 (NM_012242.2) - SHH278341 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DKK1(NM_012242.2) - SHH006131 from Creative biogene Category siRNA Species Reactivities Human

Human DKK1 siRNA - orb268392 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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