DKK1

Gene Symbol	DKK1
Entrez Gene	22943
Alt Symbol	DKK-1, SK
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 1
Other Description	dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1
Swissprots	O94907 B2RC19
Accessions	AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Subcellular Location	Secreted.
Tissue Specificity	Placenta.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-DKK1-cDNA-Clone - DC00721 from Abgent, a WuXi AppTec company Prices $359.10 Sizes 10 µg Species Human Accession NM_012242

DKK1 - MBS1273888 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001539

Human DKK1 cDNA clone(NM_012242.2) - CDFH005123 from Creative Biomart Species Human Accession NM_012242.2

Human Dkk1 ORF clone(NM_012242.2) - CDCL183922 from Creative Biomart Species Human Accession NM_012242.2

Human DKK1 ORF Clone(NM_012242.2) - CDCL161136 from Creative Biomart Species Human Accession NM_012242.2

Human DKK1 ORF Clone(NM_012242.2) - CDCR295672 from Creative Biomart Species Human Accession NM_012242.2

Human DKK1 ORF Clone(NM_012242.2) - CDCR295673 from Creative Biomart Species Human Accession NM_012242.2

Human DKK1 ORF Clone(NM_012242.2) - CDCR295726 from Creative Biomart Species Human Accession NM_012242.2

Human DKK1/Dkk-1 Gene ORF cDNA clone in cloning vector - HG10170-M from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10170-CF from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10170-NM from Sino Biological Species Human

Human Dkk1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG10170-NY from Sino Biological Species Human Accession NM_012242.2

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10170-ACG from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10170-CM from Sino Biological Species Human

Human Dkk1 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged - HG10170-M-M from Sino Biological Species Human Accession NM_012242.2

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10170-NH from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid - HG10170-UT from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10170-CY from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10170-CH from Sino Biological Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10170-NF from Sino Biological Species Human

Human Dkk1 ORF clone(NM_012242.2) - CDCL183922 from Creative biogene Species Human

Human DKK1 ORF Clone (BC001539) - CDCS413257 from Creative biogene Species Human Accession I1W660

Human DKK1 cDNA Clone(NM_012242.2) - CDFH005123 from Creative biogene Species Human

Human DKK1/Dkk-1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10170-ACR from Sino Biological Species Human

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