DKK1

Gene Symbol	DKK1
Entrez Gene	22943
Alt Symbol	DKK-1, SK
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 1
Other Description	dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1
Swissprots	O94907 B2RC19
Accessions	AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Subcellular Location	Secreted.
Tissue Specificity	Placenta.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DKK1 full length protein - ab155623 from Abcam Category Protein Prices $465.00 Sizes 100 µg Source HEK 293 cells Species Human

DKK1 peptide - ab45610 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human DKK1 full length protein - ab156969 from Abcam Category Protein Source E. coli Species Human

Human DKK1 full length protein - ab87416 from Abcam Category Protein Source Baculovirus infected High-5 cells Species Human

Human DKK1 full length protein - ab82115 from Abcam Category Protein Source HEK 293 cells Species Human

Human DKK1 peptide - ab101729 from Abcam Category Peptide

Mouse DKK1 full length protein - ab113191 from Abcam Category Protein Source E. coli Species Mouse

DKK1 Antibody Blocking Peptide - LS-E25759 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK1 Antibody Blocking Peptide - LS-E28647 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DKK1 Antibody Blocking Peptide - LS-E28646 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DKK1 Antibody Blocking Peptide - LS-E28648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DKK1 Antibody Blocking Peptide - LS-E28649 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DKK1 Antibody Blocking Peptide - LS-E17376 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK1 Antibody Blocking Peptide - LS-E10212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Human Dkk-1 Biologically Active Protein - NBP2-35343 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 2 µg, 10 µg Species Human

Recombinant Human Dkk-1 Protein - H00022943-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Dkk-1 Partial Recombinant Protein - H00022943-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Dkk-1 Protein - NBC1-21050 from Novus Biologicals Category Protein Prices $329.00 Sizes 10 µg Source Baculovirus Species Human

Recombinant Human Dkk-1 Protein - NBP2-22999 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

DKK1-Antibody-N-term-Blocking-Peptide - BP9599a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK1 Recombinant Protein - GTX48048-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source Human Species Human

DKK1 blocking peptide - GTX89683-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Pig, Rat, Bovine

Recombinant Human Dkk-1 - 5439-DK-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr32-His266

Recombinant Human Dkk-1, CF - 5439-DK-010/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr32-His266

Recombinant Human Dkk-1, CF - 5439-DK-01M/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr32-His266

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