DKK1

Gene Symbol	DKK1
Entrez Gene	22943
Alt Symbol	DKK-1, SK
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 1
Other Description	dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1
Swissprots	O94907 B2RC19
Accessions	AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Subcellular Location	Secreted.
Tissue Specificity	Placenta.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DKK1-Over-expression-Lysate - LY10186a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

DKK1 293 Cell Lysate - 401921 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Xenopus

Dkk-1 Overexpression Lysate (Native) - NBL1-09901 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DKK1 Over-expression Lysate Product - GWB-27AD33 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Rhesus DKK-1 / Dkk1 (256 Asn/Gln) HEK293 Cell Lysate (WB positive control) - 11089-K08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Rhesus DKK-1 / Dkk1 (256 Asn/Gln) HEK293 Cell Lysate (WB positive control) - 11089-K05HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Human DKK1 / Dkk-1 HEK293 Cell Lysate (WB positive control) - 10170-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Dkk-1 Overexpression Lysate (Denatured) - H00022943-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human DKK1 Human Cells Transfected Lysate (positive control) (denatured) - orb172874 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human DKK1 Knockdown Stable Cell Line - CSC-DC004327 from Creative biogene Category Cell Line Species Human

Human DKK1 Knockout Cell Line-HeLa - CSC-RT0554 from Creative biogene Category Cell Line Species Human

DKK1 KO Cell Lysate-HeLa - CLKO-0059 from Creative biogene Category Cell Lysate

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