Gene Symbol | DKK1 |
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Entrez Gene | 22943 |
Alt Symbol | DKK-1, SK |
Species | Human |
Gene Type | protein-coding |
Description | dickkopf WNT signaling pathway inhibitor 1 |
Other Description | dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1 |
Swissprots | O94907 B2RC19 |
Accessions | AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374 |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}. |
Subcellular Location | Secreted. |
Tissue Specificity | Placenta. |
Top Pathways | Wnt signaling pathway |
DKK1 Antibody - 4687 from Cell Signaling Technology
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Dkk-1 (B-7) - sc-374574 from Santa Cruz Biotechnology
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Dkk-1 (G-18) - sc-30785 from Santa Cruz Biotechnology
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Dkk-1 (H-14) - sc-30784 from Santa Cruz Biotechnology
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Dkk-1 (H-120) - sc-25516 from Santa Cruz Biotechnology
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Dkk-1 (S-20) - sc-30782 from Santa Cruz Biotechnology
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Dkk-1 (Y-17) - sc-14949 from Santa Cruz Biotechnology
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Anti-DKK1 antibody - ab61034 from Abcam
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Anti-DKK1 antibody - ab93017 from Abcam
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Anti-DKK1 antibody - ab88334 from Abcam
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Anti-DKK1 antibody - ab22827 from Abcam
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Anti-DKK1 antibody - ab139312 from Abcam
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Anti-DKK1 antibody - ab56905 from Abcam
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Anti-DKK1 antibody [EPR4759] - ab109416 from Abcam
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Anti-DKK1 Antibody (aa45-73) - LS-C3385 from LifeSpan Bioscience
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Anti-DKK1 Antibody (C-Terminus) - LS-C6401 from LifeSpan Bioscience
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Anti-DKK1 Antibody - LS-C47458 from LifeSpan Bioscience
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Anti-DKK1 Antibody (Gln75) - LS-C64738 from LifeSpan Bioscience
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Anti-DKK1 Antibody - LS-C64746 from LifeSpan Bioscience
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Anti-DKK1 Antibody - LS-C121732 from LifeSpan Bioscience
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Anti-DKK1 Antibody (aa150-200) - LS-C47394 from LifeSpan Bioscience
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Anti-DKK1 Antibody (clone 2B12) - LS-C105116 from LifeSpan Bioscience
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Anti-DKK1 Antibody (clone 2A5) - LS-C105117 from LifeSpan Bioscience
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Anti-DKK1 Antibody (clone 2H2) - LS-C108793 from LifeSpan Bioscience
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Anti-DKK1 Antibody (C-Terminus) - LS-C81144 from LifeSpan Bioscience
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