DKK1

Gene Symbol DKK1
Entrez Gene 22943
Alt Symbol DKK-1, SK
Species Human
Gene Type protein-coding
Description dickkopf WNT signaling pathway inhibitor 1
Other Description dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1
Swissprots O94907 B2RC19
Accessions AAG15544 BAA34651 CAL40393 CAM84952 CAR82120 CCA61731 CCA64135 CCA64580 CCA64583 EAW54144 O94907 AF127563 AAD21087 AF177394 AAF02674 AK314902 BAG37416 AY359005 AAQ89364 BC001539 AAH01539 BU752259 BX952450 DQ892222 ABM83148 DQ895421 ABM86347 JN966744 AFI61647 NM_012242 NP_036374
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Subcellular Location Secreted.
Tissue Specificity Placenta.
Top Pathways Wnt signaling pathway

DKK1 Antibody - 4687 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of COS cell extracts, untransfected or transiently transfected with a construct expressing DKK1, using DKK1 Antibody.

Dkk-1 (B-7) - sc-374574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dkk-1 (B-7): sc-374574. Western blot analysis of human recombinant Dkk-1.

Dkk-1 (G-18) - sc-30785 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Dkk-1 (H-14) - sc-30784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Dkk-1 (H-120) - sc-25516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dkk-1 (H-120): sc-25516. Western blot analysis of Dkk-1 expression of in JEG-3 whole cell lysate.

Dkk-1 (S-20) - sc-30782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dkk-1 (S-20): sc-30782. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cell surface staining of decidual cells.

Dkk-1 (Y-17) - sc-14949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DKK1 antibody - ab61034 from Abcam

Prices $391.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab61034 at 10µg/ml staining formalin fixed paraffin embedded Uterus (endometrium)

Anti-DKK1 antibody - ab93017 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DKK1 antibody (ab93017) at 1 µg/mlLane 1 : PC3 (Human prostate cancer cell line) Whole Cell Lysate (ab3954)Lane 2 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 3 : MDA-MB-231 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

Anti-DKK1 antibody - ab88334 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-DKK1 antibody (ab88334) at 1 µg/ml + HeLa cell lysate at 25 µgSecondaryGoat anti-Mouse IgG at 1/5000 dilution

Anti-DKK1 antibody - ab22827 from Abcam

Host Goat
Clonality Polyclonal
Anti-DKK1 antibody (ab22827) at 1 µg/ml + Human Bone Marrow lysate (35µg protein in RIPA buffer).

Anti-DKK1 antibody - ab139312 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-DKK1 antibody (ab139312) at 1/500 dilution + HepG2 cell extract

Anti-DKK1 antibody - ab56905 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DKK1 antibody [EPR4759] - ab109416 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4759
All lanes : Anti-DKK1 antibody [EPR4759] (ab109416) at 1/1000 dilutionLane 1 : JAR cell lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLane 4 : NCCIT cell lysateLysates/proteins at 10 µg per lane.

Anti-DKK1 Antibody (aa45-73) - LS-C3385 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DKK1 Antibody (C-Terminus) - LS-C6401 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DKK1 Antibody - LS-C47458 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-DKK1 Antibody (Gln75) - LS-C64738 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK1 Antibody - LS-C64746 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-DKK1 Antibody - LS-C121732 from LifeSpan Bioscience

Prices $695.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DKK1 Antibody (aa150-200) - LS-C47394 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of human DKK1 in A549 cell lysate in the 1) absence and 2) presence of immunizing peptide, and 3) RAW using antibody at 1 ug/ml.

Anti-DKK1 Antibody (clone 2B12) - LS-C105116 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B12
DKK1 monoclonal antibody (M08), clone 2B12 Western blot of DKK1 expression in HeLa.

Anti-DKK1 Antibody (clone 2A5) - LS-C105117 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A5
DKK1 monoclonal antibody (M11), clone 2A5 Western blot of DKK1 expression in U-2 OS.

Anti-DKK1 Antibody (clone 2H2) - LS-C108793 from LifeSpan Bioscience

Prices $320.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H2
Western blot using DKK1 mouse monoclonal antibody against HEK293 (1) and DKK1-hIgGFc transfected HEK293 cell lysate (2).

Anti-DKK1 Antibody (C-Terminus) - LS-C81144 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.
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