SIRT3

Gene Symbol	SIRT3
Entrez Gene	23410
Alt Symbol	SIR2L3
Species	Human
Gene Type	protein-coding
Description	sirtuin 3
Other Description	NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3
Swissprots	Q9Y6E8 B7Z5U6 Q9NTG7
Accessions	CAL00156 CAL00157 CAL48199 CAN36293 EAW61239 EAW61240 EAW61241 EAW61242 EAW61243 Q9NTG7 AA279020 AF083108 AAD40851 AI091200 AK074992 AK298572 BAH12816 AK299009 BAH12927 AK299438 BAH13032 AK301558 BAH13513 AK301979 BAH13600 AK308681 AK316175 BAH14546 AL137276 CAB70674 AL535769 BC001042 AAH01042 BI755839 BM709066 BM973763 DR762907 XM_005252835 XP_005252892 XM_011519956 XP_011518258 XM_011519957 XP_011518259 NM_001017524 NP_001017524 NM_012239 NP_036371
Function	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRT3 Activity Assay Kit (Fluorometric) - ab156067 from Abcam Category Cellular Assay Prices $464.00 Sizes 100 tests

Rat SIRT3 / Sirtuin 3 ELISA Kit (Sandwich ELISA) - LS-F6967 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Human SIRT3 / Sirtuin 3 ELISA Kit (Sandwich ELISA) - LS-F8295 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.127 ng/ml Range 0.156-10 ng/ml

Mouse SIRT3 / Sirtuin 3 ELISA Kit (Sandwich ELISA) - LS-F9476 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.156-10 ng/ml

Sirtuin 3/SIRT3 Fluorometric Assay Kit - KA1369 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3), Human, ELISA Kit - CSB-EL021341HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NAD-dependent deacetylase sirtuin-3, mitochondrial, SIRT3, Human, ELISA Kit - E2135h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Sirtuin 3 (SIRT3), Human, ELISA Kit - SEE913Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

SIRT3 Direct Fluorescent Screening Assay Kit - KA1369 from Acris Antibodies Category ELISA Kit Prices $470.00 Sizes 1 kit

sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) , ELISA Kit - MBS901737 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SIRT3 is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 15.6 pg/ml-1000 pg/ml.

Sirtuin 3 (SIRT3), ELISA Kit - MBS2022533 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.112ng/mL. Range 0.312-20ng/mL.

ELISA Kit for Sirtuin 3 (SIRT3) - SEE913Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.127ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Sirtuin 3 (SIRT3) - SEE913Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Sirtuin 3 (SIRT3) - SEE913Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human NAD-dependent deacetylase sirtuin-3, mitochondrial(SIRT3) ELISA kit - CSB-EL021341HU from Cusabio Category ELISA Kit Sensitivity 3.9pg/ml Range 15.6 pg/ml-1000 pg/ml

ELISA Kit for Sirtuin 3 (SIRT3) - SEE913Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.127ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SIRT3 / Sirtuin 3 ELISA Kit (Sandwich ELISA) - LS-F19335 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.156-10 ng/ml

Mouse SIRT3 / Sirtuin 3 ELISA Kit (Custom ELISA) - LS-F19334 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Sirtuin 3 (SIRT3) ELISA Kit - EKU07352 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.112 ng/mL Range 0.312-20 ng/mL

Human Sirtuin 3 ELISA Kit - abx153094 from Abbexa Category ELISA Kit Sensitivity 0.124 ng/ml Range 0.313 ng/ml - 20 ng/ml

Custom Human Sirtuin 3 ELISA - ELH-SIRT3 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Sirtuin 3 (SIRT3), Human, ELISA Kit - DL-SIRT3-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human SIRT3 ELISA Kit - abx572811 from Abbexa Category ELISA Kit Sensitivity 0.124 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Sirtuin 3 ELISA - RAB1701 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3) ELISA Kit - EKC34729 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

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