SIRT3

Gene Symbol SIRT3
Entrez Gene 23410
Alt Symbol SIR2L3
Species Human
Gene Type protein-coding
Description sirtuin 3
Other Description NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3
Swissprots Q9Y6E8 B7Z5U6 Q9NTG7
Accessions CAL00156 CAL00157 CAL48199 CAN36293 EAW61239 EAW61240 EAW61241 EAW61242 EAW61243 Q9NTG7 AA279020 AF083108 AAD40851 AI091200 AK074992 AK298572 BAH12816 AK299009 BAH12927 AK299438 BAH13032 AK301558 BAH13513 AK301979 BAH13600 AK308681 AK316175 BAH14546 AL137276 CAB70674 AL535769 BC001042 AAH01042 BI755839 BM709066 BM973763 DR762907 XM_005252835 XP_005252892 XM_011519956 XP_011518258 XM_011519957 XP_011518259 NM_001017524 NP_001017524 NM_012239 NP_036371
Function NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
Top Pathways Central carbon metabolism in cancer

SirT3 (C73E3) Rabbit mAb - 2627 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C73E3
Western blot analysis of various cell extracts using SirT3 (C73E3) Rabbit mAb.

SirT3 (D22A3) Rabbit mAb - 5490 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D22A3
Western blot analysis of mitochondrial extracts from SirT3 wild-type (WT) and knockout (KO) mouse liver, and of whole cell extracts from rat liver and human kidney, using SirT3 (D22A3) Rabbit mAb (upper) and AIF (D39D2) XP ® Rabbit mAb #5318 (lower).

SIRT3 (F-10) - sc-365175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRT3 (F-10): sc-365175. Western blot analysis of SIRT3 expression in Y79 whole cell lysate.

SIRT3 (N-18) - sc-49743 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SIRT3 (H-40) - sc-99143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SIRT3 (H-40): sc-99143. Western blot analysis of human recombinant SIRT3 fusion protein.

SIRT3 (P-19) - sc-49744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRT3 (P-19): sc-49744. Western blot analysis of SIRT3 expression in Hep G2 whole cell lysate.

SIRT3 (14.27) - sc-135795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SIRT3 (14.45) - sc-135796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-SIRT3 antibody - ab189860 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRT3 antibody (ab189860) at 1/500 dilutionLane 1 : Mouse brain cell extractLane 2 : HepG2 cell extract

Anti-SIRT3 antibody - ab45067 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRT3 antibody (ab45067) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SIRT3 antibody - ab118334 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-SIRT3 antibody (ab118334) at 0.3 µg/ml (for 1 hour) + Mouse Heart lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-SIRT3 antibody - ab75434 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT3 antibody (ab75434) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SIRT3 antibody - ab40963 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT3 antibody (ab40963) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-SIRT3 antibody - ab168659 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SIRT3 antibody (ab168659) at 1 µg/mlLane 1 : SIRT3 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.

Anti-SIRT3 antibody - C-terminal - ab137689 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT3 antibody - C-terminal (ab137689) at 1/1000 dilution + whole cell lysate prepared from HepG2 cells at 30 µg

Anti-SIRT3 / Sirtuin 3 Antibody (aa265-280) - LS-C3392 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT3 / Sirtuin 3 Antibody - LS-C10182 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-SIRT3 / Sirtuin 3 Antibody (C-Terminus) - LS-C46967 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT3 / Sirtuin 3 Antibody (aa152-201) - LS-C31604 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-SIRT3 / Sirtuin 3 Antibody - LS-C153166 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT3 / Sirtuin 3 Antibody (C-Terminus) - LS-C31605 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Fetal Thymus Lysate

Anti-SIRT3 / Sirtuin 3 Antibody (aa388-399) - LS-C55469 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.2 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SIRT3 / Sirtuin 3 Antibody (aa387) - LS-C190247 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT3 / Sirtuin 3 Antibody - LS-C75838 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Western blot of various cell extracts using LS-C75838.

Anti-SIRT3 / Sirtuin 3 Antibody (aa229-259, APC) - LS-C217508 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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