SIRT3

Gene Symbol	SIRT3
Entrez Gene	23410
Alt Symbol	SIR2L3
Species	Human
Gene Type	protein-coding
Description	sirtuin 3
Other Description	NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3
Swissprots	Q9Y6E8 B7Z5U6 Q9NTG7
Accessions	CAL00156 CAL00157 CAL48199 CAN36293 EAW61239 EAW61240 EAW61241 EAW61242 EAW61243 Q9NTG7 AA279020 AF083108 AAD40851 AI091200 AK074992 AK298572 BAH12816 AK299009 BAH12927 AK299438 BAH13032 AK301558 BAH13513 AK301979 BAH13600 AK308681 AK316175 BAH14546 AL137276 CAB70674 AL535769 BC001042 AAH01042 BI755839 BM709066 BM973763 DR762907 XM_005252835 XP_005252892 XM_011519956 XP_011518258 XM_011519957 XP_011518259 NM_001017524 NP_001017524 NM_012239 NP_036371
Function	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SIRT3 protein fragment - ab125810 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human SIRT3 protein fragment - ab54333 from Abcam Category Protein Prices $492.00 Sizes 100 µg Source E. coli Species Human

Human SIRT3 full length protein - ab125586 from Abcam Category Protein Source E. coli Species Human

Human SIRT3 peptide - ab45065 from Abcam Category Peptide

Human SIRT3 peptide - ab45066 from Abcam Category Peptide

Human SIRT3 protein fragment - ab97951 from Abcam Category Protein Source E. coli Species Human

SIRT3 peptide - ab176315 from Abcam Category Peptide

SIRT3 peptide (246-257) - ab45830 from Abcam Category Peptide Species Human

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E3397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E27704 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E8147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E8146 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E30933 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E11338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E11339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT3 / Sirtuin 3 Antibody Blocking Peptide - LS-E25972 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Sirtuin 3/SIRT3 Protein - H00023410-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Sirtuin 3/SIRT3 Protein - H00023410-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Sirtuin 3/SIRT3 Protein - NBP1-45302 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E.coli Species Human

Sirtuin 3/SIRT3 Blocking Peptide - NBP1-76264PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SIRT3-Antibody-N-term-Blocking-Peptide - BP14573a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT3-Antibody-C-term-Blocking-Peptide - BP6242a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT3 blocking peptide - GTX89507-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

SIRT3 Peptide - GTX85105-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human Sirtuin 3/SIRT3, CF - 7488-DA-050 from R&D Systems Category Protein Source E. coli-derived, Ser101-Lys399, with an N-terminal Met and 6-His tag

Search more