SIRT3

Gene Symbol SIRT3
Entrez Gene 23410
Alt Symbol SIR2L3
Species Human
Gene Type protein-coding
Description sirtuin 3
Other Description NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3
Swissprots Q9Y6E8 B7Z5U6 Q9NTG7
Accessions CAL00156 CAL00157 CAL48199 CAN36293 EAW61239 EAW61240 EAW61241 EAW61242 EAW61243 Q9NTG7 AA279020 AF083108 AAD40851 AI091200 AK074992 AK298572 BAH12816 AK299009 BAH12927 AK299438 BAH13032 AK301558 BAH13513 AK301979 BAH13600 AK308681 AK316175 BAH14546 AL137276 CAB70674 AL535769 BC001042 AAH01042 BI755839 BM709066 BM973763 DR762907 XM_005252835 XP_005252892 XM_011519956 XP_011518258 XM_011519957 XP_011518259 NM_001017524 NP_001017524 NM_012239 NP_036371
Function NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
Top Pathways Central carbon metabolism in cancer

SIRT3 CRISPR/Cas9 KO Plasmid (h) - sc-400675 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 HDR Plasmid (h) - sc-400675-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 Double Nickase Plasmid (h) - sc-400675-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 Double Nickase Plasmid (h2) - sc-400675-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 CRISPR Activation Plasmid (h) - sc-400675-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 CRISPR Activation Plasmid (h2) - sc-400675-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 Lentiviral Activation Particles (h) - sc-400675-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 Lentiviral Activation Particles (h2) - sc-400675-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT3 siRNA (h) - sc-61555 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT3 shRNA Plasmid (h) - sc-61555-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT3 shRNA (h) Lentiviral Particles - sc-61555-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT3-GFP shRNA (h) Lentiviral Particles - sc-61555-VG from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sirtuin 3/SIRT3 RNAi - H00023410-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU093591 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19360 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19360 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10014 from Sigma-Aldrich

Category miRNA

SIRT3 siRNA (Human) - CRH8249 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sirtuin 3/SIRT3 RNAi - H00023410-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SIRT3 - MBS827374 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SIRT3(NM_001017524.2) - SHR226554 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SIRT3(NM_012239.5) - SHR226644 from Creative biogene

Category siRNA
Species Reactivities Human

SIRT3 shRNA Plasmid (Human) - CHH8249 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SIRT3 miRNA 3'UTR clone - MiUTR1H-09413 from Creative biogene

Species Reactivities Human

SIRT3 miRNA 3'UTR clone - MiUTR1H-09414 from Creative biogene

Species Reactivities Human
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