SIRT3

Gene Symbol	SIRT3
Entrez Gene	23410
Alt Symbol	SIR2L3
Species	Human
Gene Type	protein-coding
Description	sirtuin 3
Other Description	NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3
Swissprots	Q9Y6E8 B7Z5U6 Q9NTG7
Accessions	CAL00156 CAL00157 CAL48199 CAN36293 EAW61239 EAW61240 EAW61241 EAW61242 EAW61243 Q9NTG7 AA279020 AF083108 AAD40851 AI091200 AK074992 AK298572 BAH12816 AK299009 BAH12927 AK299438 BAH13032 AK301558 BAH13513 AK301979 BAH13600 AK308681 AK316175 BAH14546 AL137276 CAB70674 AL535769 BC001042 AAH01042 BI755839 BM709066 BM973763 DR762907 XM_005252835 XP_005252892 XM_011519956 XP_011518258 XM_011519957 XP_011518259 NM_001017524 NP_001017524 NM_012239 NP_036371
Function	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SIRT3-cDNA-Clone - DC00482 from Abgent, a WuXi AppTec company Prices $538.65 Sizes 10 µg Species Human Accession BC001042

Human SIRT3 ORF clone(NM_012239.5) - CDCL186199 from Creative Biomart Species Human Accession NM_012239.5

Human SIRT3 ORF Clone(NM_001017524.2) - CDCL175512 from Creative Biomart Species Human Accession NM_001017524.2

human SIRT3 ORF clone - CDCH080412 from Creative Biomart Species Human Accession NM_001017524

human SIRT3 ORF clone - CDCH080413 from Creative Biomart Species Human Accession NM_001017524

human SIRT3 ORF clone - CDCH080414 from Creative Biomart Species Human Accession NM_001017524

human SIRT3 ORF clone - CDCH080415 from Creative Biomart Species Human Accession NM_001017524

Human SIRT3 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG13033-G from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13033-ANG from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13033-CY from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13033-ACG from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13033-NF from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13033-NY from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13033-NM from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13033-CF from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13033-NH from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13033-CM from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13033-ACR from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13033-CH from Sino Biological Species Human

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG13033-UT from Sino Biological Species Human

Human SIRT3 ORF clone(NM_012239.5) - CDCL186199 from Creative biogene Species Human

Human SIRT3 ORF Clone (BC001042) - CDCS406594 from Creative biogene Species Human Accession Q9NTG7

Human SIRT3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13033-ANR from Sino Biological Species Human

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