SIRT3

Gene Symbol	SIRT3
Entrez Gene	23410
Alt Symbol	SIR2L3
Species	Human
Gene Type	protein-coding
Description	sirtuin 3
Other Description	NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3
Swissprots	Q9Y6E8 B7Z5U6 Q9NTG7
Accessions	CAL00156 CAL00157 CAL48199 CAN36293 EAW61239 EAW61240 EAW61241 EAW61242 EAW61243 Q9NTG7 AA279020 AF083108 AAD40851 AI091200 AK074992 AK298572 BAH12816 AK299009 BAH12927 AK299438 BAH13032 AK301558 BAH13513 AK301979 BAH13600 AK308681 AK316175 BAH14546 AL137276 CAB70674 AL535769 BC001042 AAH01042 BI755839 BM709066 BM973763 DR762907 XM_005252835 XP_005252892 XM_011519956 XP_011518258 XM_011519957 XP_011518259 NM_001017524 NP_001017524 NM_012239 NP_036371
Function	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRT3-Over-expression-Lysate - LY13335a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SIRT3 Lysate(Denatured) - H00023410-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SIRT3 Lysate(Denatured) - H00023410-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SIRT3 overexpression lysate - LY402174 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIRT3 overexpression lysate - LY422739 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIRT3 293 Cell Lysate - 401919 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SIRT3 293 Cell Lysate - 409781 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Sirtuin 3/SIRT3 Overexpression Lysate (Denatured) - H00023410-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Sirtuin 3/SIRT3 Overexpression Lysate (Denatured) - H00023410-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Sirtuin 3/SIRT3 Overexpression Lysate (Native) - NBL1-15975 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Sirtuin 3/SIRT3 Overexpression Lysate (Native) - NBL1-15976 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIRT3 Over-expression Lysate Product - GWB-BE9EE5 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

SIRT3 Over-expression Lysate Product - GWB-6D7A9E from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human SIRT3 Knockdown Stable Cell Line - CSC-DC014269 from Creative biogene Category Cell Line Species Human

SIRT3 KO Cell Lysate-HeLa - CLKO-0841 from Creative biogene Category Cell Lysate

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