UCHL3

Gene Symbol UCHL3
Entrez Gene 7347
Alt Symbol UCH-L3
Species Human
Gene Type protein-coding
Description ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Other Description ubiquitin carboxyl-terminal hydrolase isozyme L3|ubiquitin thioesterase L3|ubiquitin thiolesterase
Swissprots Q6IBE9 P15374 Q5TBK8 B2R970
Accessions CCQ43343 CCQ43344 EAW80542 EAW80543 EAW80544 EAW80545 EAW80546 EAW80547 P15374 AA234624 AK313665 BAG36417 BC018125 AAH18125 BQ427804 BT019359 AAV38166 CR456855 CAG33136 DA820150 HQ447110 ADQ31597 M30496 AAA36791 XM_011535212 XP_011533514 XM_011535213 XP_011533515 XM_011535214 XP_011533516 NM_001270952 NP_001257881 NM_006002 NP_005993
Function Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0
Subcellular Location Cytoplasm.
Tissue Specificity Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.

UCHL3 Antibody - 3525 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using UCHL3 Antibody.

UCHL3 (D25E6) Rabbit mAb - 8141 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D25E6
Western blot analysis of extracts from various cell lines using UCHL3 (D25E6) Rabbit mAb.

UCH-L3 (F-20) - sc-23855 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UCH-L3 (F-20): sc-23855. Western blot analysis of UCH-L3 expression in non-transfected: sc-110760 (A) and human UCH-L3 transfected: sc-113153 (B) 293 whole cell lysates.

UCH-L3 (ZE-17) - sc-100340 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
UCH-L3 (ZE-17): sc-100340. Western blot analysis of UCH-L3 expression in non-transfected 293: sc-110760 (A), human UCH-L3 transfected 293: sc-113153 (B) and K-562 (C) whole cell lysates.

UCH-L3/4 (C-20) - sc-23856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UCH-L3/4 (C-20): sc-23856. Western blot analysis of UCH-L3/4 expression in non-transfected: sc-110760 (A) and human UCH-L3 transfected: sc-113153 (B) 293 whole cell lysates.

Anti-UCHL3 antibody - ab57689 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-UCHL3 antibody - ab62035 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab62035 at 10µg/ml staining UCHL3 in human testis by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Anti-UCHL3 antibody [AF9G8] - ab75526 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AF9G8

Anti-UCHL3 antibody [EP5331] - ab126621 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP5331
All lanes : Anti-UCHL3 antibody [EP5331] (ab126621) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : 293T cell lysateLane 3 : SH-SY5Y cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-UCHL3 antibody [EPR5332] - ab126703 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5332
ab126703, at 1/100, staining UCHL3 in Paraffin-embedded Human testis tissue by Immunohistochemistry.

Anti-UCHL3 Antibody IHC-plus™ - LS-B7856 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Anti-UCHL3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7856 dilution 1:200.

Anti-UCHL3 Antibody (N-Terminus) IHC-plus™ - LS-B4688 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UCHL3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4688 concentration 5 ug/ml.

Anti-UCHL3 Antibody (Leu220) - LS-C76684 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody (aa2-230) - LS-C132796 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-UCHL3 Antibody (Internal) IHC-plus™ - LS-A8557 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-UCHL3 Antibody (aa1-50) - LS-C289659 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody (N-Terminus, clone EP5331) - LS-C152322 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP5331
Western blot analysis on (A) K562, (B) 293T, (C) SH-SY5Y, and (D) Jurkat cell lysates using anti-UCHL3 antibody.

Anti-UCHL3 Antibody (C-Terminus) - LS-C116945 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
UCHL3 antibody LS-C116945 Western blot of Fetal Liver lysate.

Anti-UCHL3 Antibody (aa2-230) - LS-C296903 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody (aa2-230, Biotin) - LS-C300349 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody (aa2-230, Biotin) - LS-C300348 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody (aa2-230, FITC) - LS-C302160 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody (aa101-150) - LS-C170308 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-UCHL3 Antibody - LS-C305914 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-UCHL3 Antibody (aa2-230, FITC) - LS-C302162 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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