UCHL3

Gene Symbol	UCHL3
Entrez Gene	7347
Alt Symbol	UCH-L3
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Other Description	ubiquitin carboxyl-terminal hydrolase isozyme L3|ubiquitin thioesterase L3|ubiquitin thiolesterase
Swissprots	Q6IBE9 P15374 Q5TBK8 B2R970
Accessions	CCQ43343 CCQ43344 EAW80542 EAW80543 EAW80544 EAW80545 EAW80546 EAW80547 P15374 AA234624 AK313665 BAG36417 BC018125 AAH18125 BQ427804 BT019359 AAV38166 CR456855 CAG33136 DA820150 HQ447110 ADQ31597 M30496 AAA36791 XM_011535212 XP_011533514 XM_011535213 XP_011533515 XM_011535214 XP_011533516 NM_001270952 NP_001257881 NM_006002 NP_005993
Function	Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® UCHL3 siRNA I - 7511 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® UCHL3 siRNA II - 7339 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

UCH-L3 CRISPR/Cas9 KO Plasmid (h) - sc-407454 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 HDR Plasmid (h) - sc-407454-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 Double Nickase Plasmid (h) - sc-407454-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 Double Nickase Plasmid (h2) - sc-407454-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 CRISPR Activation Plasmid (h) - sc-407454-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 CRISPR Activation Plasmid (h2) - sc-407454-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 Lentiviral Activation Particles (h) - sc-407454-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 Lentiviral Activation Particles (h2) - sc-407454-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L3 siRNA (h) - sc-42306 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UCH-L3 shRNA Plasmid (h) - sc-42306-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UCH-L3 shRNA (h) Lentiviral Particles - sc-42306-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN22435 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22435 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

UCHL3 siRNA (Human) - CRH5022 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UCH-L3 RNAi - H00007347-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

UCHL3 - MBS8226338 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UCHL3 (NM_006002.4) - SHH439764 from Creative biogene Category siRNA Species Reactivities Human

Human UCHL3 siRNA - orb265524 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UCHL3 shRNA Plasmid (Human) - CHH5022 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UCHL3 miRNA 3'UTR clone - MiUTR3H-05657 from Creative biogene Species Reactivities Human

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