UCHL3

Gene Symbol	UCHL3
Entrez Gene	7347
Alt Symbol	UCH-L3
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Other Description	ubiquitin carboxyl-terminal hydrolase isozyme L3|ubiquitin thioesterase L3|ubiquitin thiolesterase
Swissprots	Q6IBE9 P15374 Q5TBK8 B2R970
Accessions	CCQ43343 CCQ43344 EAW80542 EAW80543 EAW80544 EAW80545 EAW80546 EAW80547 P15374 AA234624 AK313665 BAG36417 BC018125 AAH18125 BQ427804 BT019359 AAV38166 CR456855 CAG33136 DA820150 HQ447110 ADQ31597 M30496 AAA36791 XM_011535212 XP_011533514 XM_011535213 XP_011533515 XM_011535214 XP_011533516 NM_001270952 NP_001257881 NM_006002 NP_005993
Function	Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human UCHL3 full length protein - ab168869 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Active human UCHL3 full length protein - ab103502 from Abcam Category Protein Prices $239.00, $883.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Active human UCHL3 protein fragment - ab125809 from Abcam Category Protein Species Human

Human UCHL3 full length protein - ab167959 from Abcam Category Protein Source E. coli Species Human

UCHL3 protein (Human) - Chemical Free - ab80736 from Abcam Category Protein Source E. coli Species Human

UCHL3 Antibody Blocking Peptide - LS-E29434 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

UCHL3 Antibody Blocking Peptide - LS-E29435 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

UCHL3 Antibody Blocking Peptide - LS-E29460 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

UCHL3 Antibody Blocking Peptide - LS-E21693 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL3 Antibody Blocking Peptide - LS-E21692 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL3 Antibody Blocking Peptide - LS-E21478 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCH-L3 Recombinant Protein - H00007347-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

UCH-L3 Partial Recombinant Protein - H00007347-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UCH-L3 Protein - NBP1-50956 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Recombinant Human UCH-L3, CF - E-325-025 from R&D Systems Category Protein Source E. coli-derived,

UCHL3 Protein (OPPA02564) - OPPA02564 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human UCHL3 protein - orb169518 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

PGP9.5 protein - 30R-1093 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

UCHL3 Blocking Peptide - 33R-5920 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UCHL3 Blocking Peptide - 33R-10087 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UCHL3 protein (His tag) - 80R-1631 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Human UCHL3 Protein - abx069587 from Abbexa Category Protein Source E.coli Species Human

UCHL3 (1-230, His-tag) - AR09812PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UCHL3 (1-230, His-tag) - AR09812PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

UCHL3 - H00007347-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

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