| Gene Symbol |
UCHL3
|
| Entrez Gene |
7347
|
| Alt Symbol |
UCH-L3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
|
| Other Description |
ubiquitin carboxyl-terminal hydrolase isozyme L3|ubiquitin thioesterase L3|ubiquitin thiolesterase
|
| Swissprots |
Q6IBE9 P15374 Q5TBK8 B2R970
|
| Accessions |
CCQ43343 CCQ43344 EAW80542 EAW80543 EAW80544 EAW80545 EAW80546 EAW80547 P15374 AA234624 AK313665 BAG36417 BC018125 AAH18125 BQ427804 BT019359 AAV38166 CR456855 CAG33136 DA820150 HQ447110 ADQ31597 M30496 AAA36791 XM_011535212 XP_011533514 XM_011535213 XP_011533515 XM_011535214 XP_011533516 NM_001270952 NP_001257881 NM_006002 NP_005993
|
| Function |
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.
|
![Western Blot: UCHL3 Overexpression Lysate (Adult Normal) [NBL1-17576] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UCHL3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9009_UCHL3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17576-img0002.jpg)