UCHL3

Gene Symbol	UCHL3
Entrez Gene	7347
Alt Symbol	UCH-L3
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Other Description	ubiquitin carboxyl-terminal hydrolase isozyme L3|ubiquitin thioesterase L3|ubiquitin thiolesterase
Swissprots	Q6IBE9 P15374 Q5TBK8 B2R970
Accessions	CCQ43343 CCQ43344 EAW80542 EAW80543 EAW80544 EAW80545 EAW80546 EAW80547 P15374 AA234624 AK313665 BAG36417 BC018125 AAH18125 BQ427804 BT019359 AAV38166 CR456855 CAG33136 DA820150 HQ447110 ADQ31597 M30496 AAA36791 XM_011535212 XP_011533514 XM_011535213 XP_011533515 XM_011535214 XP_011533516 NM_001270952 NP_001257881 NM_006002 NP_005993
Function	Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 Gene - orb92683 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-UCHL3-cDNA-Clone - DC04673 from Abgent, a WuXi AppTec company Prices $310.50 Sizes 10 µg Species Human Accession BC018125

UCHL3 - MBS1266901 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC018125

human UCHL3 ORF clone - CDCH097798 from Creative Biomart Species Human Accession NM_006002

human UCHL3 ORF clone - CDCH097799 from Creative Biomart Species Human Accession NM_006002

Human UCHL3 ORF Clone(NM_006002.4) - CDCL180424 from Creative Biomart Species Human Accession NM_006002.4

Human UCHL3 Gene ORF cDNA clone in cloning vector - HG11634-M from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11634-CM from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11634-NY from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11634-ANG from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid - HG11634-UT from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11634-ACG from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, N-His tag - HG11634-NH from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-His tag - HG11634-CH from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11634-CY from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11634-ACR from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11634-ANR from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11634-NF from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11634-CF from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11634-M-F from Sino Biological Species Human

Human UCHL3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11634-NM from Sino Biological Species Human

Human UCHL3 ORF Clone (BC018125) - CDCS412524 from Creative biogene Species Human Accession P15374

Human UCHL3 ORF clone (NM_006002.3) - CDCB160345 from Creative biogene Species Human

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