UCHL3

Gene Symbol	UCHL3
Entrez Gene	7347
Alt Symbol	UCH-L3
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Other Description	ubiquitin carboxyl-terminal hydrolase isozyme L3|ubiquitin thioesterase L3|ubiquitin thiolesterase
Swissprots	Q6IBE9 P15374 Q5TBK8 B2R970
Accessions	CCQ43343 CCQ43344 EAW80542 EAW80543 EAW80544 EAW80545 EAW80546 EAW80547 P15374 AA234624 AK313665 BAG36417 BC018125 AAH18125 BQ427804 BT019359 AAV38166 CR456855 CAG33136 DA820150 HQ447110 ADQ31597 M30496 AAA36791 XM_011535212 XP_011533514 XM_011535213 XP_011533515 XM_011535214 XP_011533516 NM_001270952 NP_001257881 NM_006002 NP_005993
Function	Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) , ELISA Kit - MBS9333757 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.5ng/ml-16ng/ml.

Custom Human UCH-L3 ELISA - ELH-UCHL3 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human UCH-L3 ELISA Kit - orb320083 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

Human UCH-L3 ELISA - RAB1767 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Custom Human UCH-L3 ELISA - ELH-UCHL3-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human UCHL3 ELISA Kit - E102004 from Biobool Category ELISA Kit

anti-UCHL3 antibody - ARG55604 from Arigo Biolaboratories Category ELISA Kit

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9367067 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9359910 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9345915 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9369070 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9368725 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9365402 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9369984 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9355830 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9353971 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9369203 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9363876 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9346936 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9360726 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9362120 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9358841 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9354827 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9371453 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3), ELISA Kit - MBS9350597 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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