TIRAP

Gene Symbol TIRAP
Entrez Gene 114609
Alt Symbol BACTS1, Mal, MyD88-2, wyatt
Species Human
Gene Type protein-coding
Description toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Other Description MyD88 adapter-like protein|Toll-like receptor adaptor protein|adapter protein wyatt|adaptor protein Wyatt|toll/interleukin-1 receptor domain-containing adapter protein
Swissprots B3KW65 Q8N5E5 Q56UI0 P58753 Q56UH9
Accessions AAP31973 EAW67687 EAW67688 EAW67689 P58753 AB446477 BAG55254 AF378129 AAL05627 AF406652 AAL01160 AF410783 AAL05036 AK124298 BAG54027 AK313147 BAG35965 AY576785 AAT90417 AY576786 AAT90418 AY576787 AAT90419 BC032474 AAH32474 DQ890988 ABM81914 DQ894164 ABM85090 XM_005271399 XP_005271456 XM_011542576 XP_011540878 XM_011542577 XP_011540879 XM_011542578 XP_011540880 XM_011542579 XP_011540881 XM_011542580 XP_011540882 XM_011542581 XP_011540883 XM_011542582 XP_011540884 NM_001039661 NP_001034750 NM_148910 NP_683708 NM_052887
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
Tissue Specificity Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Top Pathways Toll-like receptor signaling pathway, Pertussis, Tuberculosis

TIRAP (A-11) - sc-166149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIRAP (A-11): sc-166149. Western blot analysis of TIRAP expression in non-transfected: sc-117752 (A) and human TIRAP transfected: sc-114950 (B) 293T whole cell lysates.

TIRAP (N-16) - sc-19950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIRAP (N-16): sc-19950. Western blot analysis of TIRAP expression in ES-2 (A) and Caki-1 (B) whole cell lysates.

TIRAP (C-7) - sc-166150 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIRAP (C-7): sc-166150. Western blot analysis of TIRAP expression in non-transfected: sc-117752 (A) and human TIRAP transfected: sc-114950 (B) 293T whole cell lysates.

TIRAP (C-19) - sc-19952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIRAP (C-19): sc-19952. Western blot analysis of TIRAP expression in ES-2 (A) and Caki-1 (B) whole cell lysates.

TIRAP (FL-235) - sc-28822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TIRAP (FL-235): sc-28822. Western blot analysis of TIRAP expression in non-transfected: sc-117752 (A) and human TIRAP transfected: sc-114950 (B) 293T whole cell lysates.

TIRAP (H-20) - sc-31308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TIRAP (B-3) - sc-166151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIRAP (B-3): sc-166151. Western blot analysis of TIRAP expression in non-transfected: sc-117752 (A) and human TIRAP transfected: sc-114950 (B) 293T whole cell lysates.

TIRAP (T-16) - sc-31309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIRAP (T-16): sc-31309. Western blot analysis of TIRAP expression in HUV-EC-C whole cell lysate.

Anti-TIRAP (phospho Y86) antibody - ab111509 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111509, at 1/50 dilution, staining TIRAP in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-TIRAP antibody - ab17218 from Abcam

Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TIRAP antibody (ab17218) at 0.5 µg/mlLane 2 : Anti-TIRAP antibody (ab17218) at 1 µg/mlLane 3 : Anti-TIRAP antibody (ab17218) at 2 µg/mlLane 1 : heart cell lysateLane 2 : heart cell lysateLane 3 : heart cell lysateObserved band size : 35 kDa (why is the actual band size different from the predicted?)

Anti-TIRAP antibody - ab78070 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab78070, at 10 µg/ml, staining human TIRAP in skeletal muscle, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Anti-TIRAP antibody - ab1349 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-TIRAP antibody (ab1349) at 1 µg/ml + Human Liver lysate (35ug protein in RIPA buffer)

Anti-TIRAP antibody - ab47986 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TIRAP antibody (ab47986) at 0.1 µg/ml + K562 cell lysate (35µg protein in RIPA buffer).

Anti-TIRAP antibody [20D1055] - ab13684 from Abcam

Prices $370.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 20D1055

Anti-TIRAP antibody [EP1231Y] - ab52911 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1231Y
Anti-TIRAP antibody [EP1231Y] (ab52911) at 1/1000 dilution + HeLa cell lysate at 10 µg

Anti-TIRAP antibody [EPR3509] - ab133332 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3509
All lanes : Anti-TIRAP antibody [EPR3509] (ab133332) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : HUVEC cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/2000 dilution

Anti-TIRAP Antibody (Internal) - LS-C10576 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIRAP Antibody (C-Terminus) - LS-C10577 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIRAP Antibody - LS-C18718 from LifeSpan Bioscience

Prices $380.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-TIRAP Antibody (C-Terminus) - LS-C10578 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIRAP Antibody (aa1-215, clone 4H9) - LS-C53203 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 4H9

Anti-TIRAP Antibody (clone 20D1055.1) - LS-C544 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 20D1055.1
Western blot of TIRAP in human spleen lysate using LS-C544 at 1:500.

Anti-TIRAP Antibody (aa27-41) - LS-C55599 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of K562 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TIRAP Antibody (aa52-101) - LS-C291253 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIRAP Antibody (aa171-224) - LS-C311579 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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