| Gene Symbol |
TIRAP
|
| Entrez Gene |
114609
|
| Alt Symbol |
BACTS1, Mal, MyD88-2, wyatt
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
|
| Other Description |
MyD88 adapter-like protein|Toll-like receptor adaptor protein|adapter protein wyatt|adaptor protein Wyatt|toll/interleukin-1 receptor domain-containing adapter protein
|
| Swissprots |
B3KW65 Q8N5E5 Q56UI0 P58753 Q56UH9
|
| Accessions |
AAP31973 EAW67687 EAW67688 EAW67689 P58753 AB446477 BAG55254 AF378129 AAL05627 AF406652 AAL01160 AF410783 AAL05036 AK124298 BAG54027 AK313147 BAG35965 AY576785 AAT90417 AY576786 AAT90418 AY576787 AAT90419 BC032474 AAH32474 DQ890988 ABM81914 DQ894164 ABM85090 XM_005271399 XP_005271456 XM_011542576 XP_011540878 XM_011542577 XP_011540879 XM_011542578 XP_011540880 XM_011542579 XP_011540881 XM_011542580 XP_011540882 XM_011542581 XP_011540883 XM_011542582 XP_011540884 NM_001039661 NP_001034750 NM_148910 NP_683708 NM_052887
|
| Function |
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
|
| Tissue Specificity |
Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
|
| Top Pathways |
Toll-like receptor signaling pathway, Pertussis, Tuberculosis
|
