TIRAP

Gene Symbol	TIRAP
Entrez Gene	114609
Alt Symbol	BACTS1, Mal, MyD88-2, wyatt
Species	Human
Gene Type	protein-coding
Description	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Other Description	MyD88 adapter-like protein|Toll-like receptor adaptor protein|adapter protein wyatt|adaptor protein Wyatt|toll/interleukin-1 receptor domain-containing adapter protein
Swissprots	B3KW65 Q8N5E5 Q56UI0 P58753 Q56UH9
Accessions	AAP31973 EAW67687 EAW67688 EAW67689 P58753 AB446477 BAG55254 AF378129 AAL05627 AF406652 AAL01160 AF410783 AAL05036 AK124298 BAG54027 AK313147 BAG35965 AY576785 AAT90417 AY576786 AAT90418 AY576787 AAT90419 BC032474 AAH32474 DQ890988 ABM81914 DQ894164 ABM85090 XM_005271399 XP_005271456 XM_011542576 XP_011540878 XM_011542577 XP_011540879 XM_011542578 XP_011540880 XM_011542579 XP_011540881 XM_011542580 XP_011540882 XM_011542581 XP_011540883 XM_011542582 XP_011540884 NM_001039661 NP_001034750 NM_148910 NP_683708 NM_052887
Function	Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
Tissue Specificity	Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Top Pathways	Toll-like receptor signaling pathway, Pertussis, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIRAP ELISA Kit (Sandwich ELISA) - LS-F8800 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.109 ng/ml Range 0.313-20 ng/ml

Myelin and lymphocyte protein, MAL, Human, ELISA Kit - E1968h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Toll Interleukin 1 Receptor Domain Containing Adaptor Protein (TIRAP), Human, ELISA Kit - SEN888Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.109ng/mL Range 0.312-20ng/mL

TIRAP (Human) IP-WB Antibody Pair - H00114609-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

toll-interleukin 1 receptor (TIR) domain containing adaptor protein, ELISA Kit - MBS9324448 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Toll Interleukin 1 Receptor Domain Containing Adaptor Protein (TIRAP) - SEN888Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.109ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Toll Interleukin 1 Receptor Domain Containing Adaptor Protein (TIRAP) - SEN888Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.109ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human TIRAP ELISA Kit (Custom ELISA) - LS-F19943 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse TIRAP ELISA Kit (Custom ELISA) - LS-F19944 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human TIRAP ELISA Kit - abx153305 from Abbexa Category ELISA Kit Sensitivity 0.109 ng/ml Range 0.313 ng/ml - 20 ng/ml

Cluster Of Differentiation 8a (CD8a), Human, ELISA Kit - DL-CD8a-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 3.12 -200 ng/mL

Toll Interleukin 1 Receptor Domain Containing Adaptor Protein (TIRAP), Human, ELISA Kit - DL-TIRAP-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human TIRAP ELISA Kit - abx572966 from Abbexa Category ELISA Kit Sensitivity 0.109 ng/ml Range 0.313 ng/ml - 20 ng/ml

TIRAP - EKH4592 from Nordic BioSite Sensitivity 18.75pg/ml Range 31.2-2000pg/ml

TIRAP ELISA Kit (Human) : 96 Wells (OKEH01734) - OKEH01734 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 15 pg/mL Range 31.2 - 2000 pg/mL

Human MAL ELISA Kit - E023512 from Biobool Category ELISA Kit

Human TIRAP ELISA Kit - E038524 from Biobool Category ELISA Kit Sensitivity Typically less than 0.109ng/mL.

Human Toll/interleukin-1 receptor domain-containing adapter protein ELISA Kit - EK4642 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 20pg/mL Range 78-5000 pg/mL

anti-TIRAP antibody - ARG55409 from Arigo Biolaboratories Category ELISA Kit

anti-TIRAP / Mal antibody - ARG63640 from Arigo Biolaboratories Category ELISA Kit

anti-TIRAP antibody - ARG63941 from Arigo Biolaboratories Category ELISA Kit

Toll Interleukin 1 Receptor Domain Containing Adaptor Protein (TIRAP), ELISA Kit - MBS454569 from MyBioSource Category ELISA Kit Prices $405.00, $535.00, $2,340.00, $4,545.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.109ng/mL Range 0.312-20ng/mL

Toll/interleukin-1 receptor domain-containing adapter protein, ELISA Kit - MBS2884336 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 31.2-2000 pg/mL

Toll/interleukin-1 receptor domain-containing adapter protein, ELISA Kit - MBS9428468 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 15pg/mL Range 31.2-2000 pg/mL

Human TIRAP ELISA Kit (Sandwich ELISA) - LS-F33719 from LifeSpan Bioscience Category ELISA Kit Sensitivity 18.75 Range 0.313-20 ng/ml

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