TIRAP

Gene Symbol	TIRAP
Entrez Gene	114609
Alt Symbol	BACTS1, Mal, MyD88-2, wyatt
Species	Human
Gene Type	protein-coding
Description	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Other Description	MyD88 adapter-like protein|Toll-like receptor adaptor protein|adapter protein wyatt|adaptor protein Wyatt|toll/interleukin-1 receptor domain-containing adapter protein
Swissprots	B3KW65 Q8N5E5 Q56UI0 P58753 Q56UH9
Accessions	AAP31973 EAW67687 EAW67688 EAW67689 P58753 AB446477 BAG55254 AF378129 AAL05627 AF406652 AAL01160 AF410783 AAL05036 AK124298 BAG54027 AK313147 BAG35965 AY576785 AAT90417 AY576786 AAT90418 AY576787 AAT90419 BC032474 AAH32474 DQ890988 ABM81914 DQ894164 ABM85090 XM_005271399 XP_005271456 XM_011542576 XP_011540878 XM_011542577 XP_011540879 XM_011542578 XP_011540880 XM_011542579 XP_011540881 XM_011542580 XP_011540882 XM_011542581 XP_011540883 XM_011542582 XP_011540884 NM_001039661 NP_001034750 NM_148910 NP_683708 NM_052887
Function	Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
Tissue Specificity	Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Top Pathways	Toll-like receptor signaling pathway, Pertussis, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIRAP full length protein - ab132974 from Abcam Category Protein Source Wheat germ Species Human

Human TIRAP full length protein - ab131663 from Abcam Category Protein Source E. coli Species Human

Human TIRAP peptide - ab45452 from Abcam Category Peptide Species Human

Human TIRAP peptide - ab48036 from Abcam Category Peptide Species Human

MAL Antibody Blocking Peptide - LS-E26369 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIRAP Antibody Blocking Peptide - LS-E25248 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIRAP Antibody Blocking Peptide - LS-E19056 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIRAP Antibody Blocking Peptide - LS-E25973 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIRAP Antibody Blocking Peptide - LS-E30026 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TIRAP Antibody Blocking Peptide - LS-E30025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TIRAP (TLR2 and TLR4) Recombinant Protein - H00114609-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MAL Protein - H00004118-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TIRAP (TLR2 and TLR4) Protein - NBP2-22871 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

TIRAP (TLR2 and TLR4) Peptide - NBP1-77226PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

TIRAP blocking peptide - GTX89359-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TIRAP/Mal (Isoform b) blocking peptide - GTX89676-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human TIRAP protein - orb169436 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

CD8 Immunizing peptide - orb16908 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TIRAP Immunizing peptide - orb17967 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TIRAP Blocking Peptide - 33R-4901 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TIRAP protein (His tag) - 80R-2419 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

TIRAP Peptide - AC21-0075-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TIRAP Peptide - AC21-0800-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TIRAP (1-221, His-tag) - AR50499PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

TIRAP (1-221, His-tag) - AR50499PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

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