TIRAP

Gene Symbol TIRAP
Entrez Gene 114609
Alt Symbol BACTS1, Mal, MyD88-2, wyatt
Species Human
Gene Type protein-coding
Description toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Other Description MyD88 adapter-like protein|Toll-like receptor adaptor protein|adapter protein wyatt|adaptor protein Wyatt|toll/interleukin-1 receptor domain-containing adapter protein
Swissprots B3KW65 Q8N5E5 Q56UI0 P58753 Q56UH9
Accessions AAP31973 EAW67687 EAW67688 EAW67689 P58753 AB446477 BAG55254 AF378129 AAL05627 AF406652 AAL01160 AF410783 AAL05036 AK124298 BAG54027 AK313147 BAG35965 AY576785 AAT90417 AY576786 AAT90418 AY576787 AAT90419 BC032474 AAH32474 DQ890988 ABM81914 DQ894164 ABM85090 XM_005271399 XP_005271456 XM_011542576 XP_011540878 XM_011542577 XP_011540879 XM_011542578 XP_011540880 XM_011542579 XP_011540881 XM_011542580 XP_011540882 XM_011542581 XP_011540883 XM_011542582 XP_011540884 NM_001039661 NP_001034750 NM_148910 NP_683708 NM_052887
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
Tissue Specificity Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Top Pathways Toll-like receptor signaling pathway, Pertussis, Tuberculosis

Human-TIRAP-cDNA-Clone - DC06401 from Abgent, a WuXi AppTec company

Prices $345.60
Sizes 10 µg
Species Human
Accession BC032474

TIRAP - MBS1273403 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC032474

Human TIRAP cDNA clone(NM_001039661.1) - CDFH019651 from Creative Biomart

Species Human
Accession NM_001039661.1

human TIRAP ORF clone - CDCH091228 from Creative Biomart

Species Human
Accession NM_001039661

human TIRAP ORF clone - CDCH091229 from Creative Biomart

Species Human
Accession NM_001039661

human TIRAP ORF clone - CDCH091230 from Creative Biomart

Species Human
Accession NM_001039661

human TIRAP ORF clone - CDCH091231 from Creative Biomart

Species Human
Accession NM_001039661

human TIRAP ORF clone - CDCH091232 from Creative Biomart

Species Human
Accession NM_001039661

human TIRAP ORF clone - CDCH091233 from Creative Biomart

Species Human
Accession NM_001039661

Human TIRAP ORF Clone(NM_001039661.1) - CDCL178548 from Creative Biomart

Species Human
Accession NM_001039661.1

Human TIRAP ORF Clone(NM_001039661.1) - CDCL178549 from Creative Biomart

Species Human
Accession NM_001039661.1

Human TIRAP ORF Clone(NM_148910.2) - CDCR318943 from Creative Biomart

Species Human
Accession NM_148910.2

Human TIRAP ORF Clone(NM_148910.2) - CDCR318944 from Creative Biomart

Species Human
Accession NM_148910.2

Human TIRAP ORF Clone(NM_001039661.1) - CDCR343817 from Creative Biomart

Species Human
Accession NM_001039661.1

Human TIRAP ORF Clone(NM_001039661.1) - CDCR343818 from Creative Biomart

Species Human
Accession NM_001039661.1

Human TIRAP ORF Clone(NM_001039661.1) - CDCR343819 from Creative Biomart

Species Human
Accession NM_001039661.1

Human TIRAP ORF Clone(NM_001039661.1) - CDCR343817 from Creative biogene

Species Human

human TIRAP ORF clone (NM_148910.2) - CDCH091228 from Creative biogene

Species Human

Human TIRAP ORF Clone (BC032474) - CDCS406975 from Creative biogene

Species Human
Accession P58753

Human TIRAP cDNA Clone(NM_001039661.1) - CDFH019651 from Creative biogene

Species Human
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