TIRAP
| Gene Symbol | TIRAP |
|---|---|
| Entrez Gene | 114609 |
| Alt Symbol | BACTS1, Mal, MyD88-2, wyatt |
| Species | Human |
| Gene Type | protein-coding |
| Description | toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
| Other Description | MyD88 adapter-like protein|Toll-like receptor adaptor protein|adapter protein wyatt|adaptor protein Wyatt|toll/interleukin-1 receptor domain-containing adapter protein |
| Swissprots | B3KW65 Q8N5E5 Q56UI0 P58753 Q56UH9 |
| Accessions | AAP31973 EAW67687 EAW67688 EAW67689 P58753 AB446477 BAG55254 AF378129 AAL05627 AF406652 AAL01160 AF410783 AAL05036 AK124298 BAG54027 AK313147 BAG35965 AY576785 AAT90417 AY576786 AAT90418 AY576787 AAT90419 BC032474 AAH32474 DQ890988 ABM81914 DQ894164 ABM85090 XM_005271399 XP_005271456 XM_011542576 XP_011540878 XM_011542577 XP_011540879 XM_011542578 XP_011540880 XM_011542579 XP_011540881 XM_011542580 XP_011540882 XM_011542581 XP_011540883 XM_011542582 XP_011540884 NM_001039661 NP_001034750 NM_148910 NP_683708 NM_052887 |
| Function | Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane. |
| Tissue Specificity | Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. |
| Top Pathways | Toll-like receptor signaling pathway, Pertussis, Tuberculosis |
TIRAP CRISPR/Cas9 KO Plasmid (h) - sc-402650 from Santa Cruz Biotechnology
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TIRAP HDR Plasmid (h) - sc-402650-HDR from Santa Cruz Biotechnology
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TIRAP Double Nickase Plasmid (h) - sc-402650-NIC from Santa Cruz Biotechnology
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TIRAP Double Nickase Plasmid (h2) - sc-402650-NIC-2 from Santa Cruz Biotechnology
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TIRAP CRISPR Activation Plasmid (h) - sc-402650-ACT from Santa Cruz Biotechnology
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TIRAP CRISPR Activation Plasmid (h2) - sc-402650-ACT-2 from Santa Cruz Biotechnology
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TIRAP Lentiviral Activation Particles (h) - sc-402650-LAC from Santa Cruz Biotechnology
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TIRAP Lentiviral Activation Particles (h2) - sc-402650-LAC-2 from Santa Cruz Biotechnology
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TIRAP siRNA (h) - sc-42932 from Santa Cruz Biotechnology
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TIRAP shRNA Plasmid (h) - sc-42932-SH from Santa Cruz Biotechnology
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TIRAP shRNA (h) Lentiviral Particles - sc-42932-V from Santa Cruz Biotechnology
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TIRAP RNAi - H00114609-R03 from Novus Biologicals
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TIRAP RNAi - H00114609-R04 from Novus Biologicals
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MISSION® esiRNA - EHU022251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21377 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21377 from Sigma-Aldrich
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TIRAP siRNA (Human) - CRJ4360 from Cohesion Biosciences
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TIRAP - MBS8223117 from MyBioSource
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shRNA set against Human TIRAP (NM_001039661.1) - SHH427648 from Creative biogene
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shRNA set against Human TIRAP(NM_148910.2) - SHL071934 from Creative biogene
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shRNA set against Human TIRAP(NM_001039661.1) - SHL071936 from Creative biogene
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shRNA set against Human TIRAP(NM_148910.2) - SHL072054 from Creative biogene
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TIRAP shRNA Plasmid (Human) - CHJ4360 from Cohesion Biosciences
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TIRAP miRNA 3'UTR clone - MiUTR1H-10422 from Creative biogene
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TIRAP miRNA 3'UTR clone - MiUTR1H-10423 from Creative biogene
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